{"id":"W3195024161","doi":"10.1111/bjh.17811","title":"Molecular profiling in diffuse large B‐cell lymphoma: why so many types of subtypes?","year":2021,"lang":"en","type":"review","venue":"British Journal of Haematology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Genome British Columbia; Spinal Cord Injury BC; Simon Fraser University","funders":"Medical Research Council; National Institute for Health and Care Research; Michael Smith Health Research BC; Cancer Research UK; NIHR Cambridge Biomedical Research Centre; Wellcome Trust","keywords":"Subtyping; Computational biology; Lymphoma; Profiling (computer programming); Precision medicine; Diffuse large B-cell lymphoma; Clinical trial; Bioinformatics; Biology; Medicine; Computer science; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003695635,0.0003286722,0.004404874,0.0003709564,0.00003671662,0.00003487616,0.0002125589,0.0004490256,0.00007373502],"category_scores_gemma":[0.0002431725,0.0003033516,0.0009670276,0.0003127539,0.00009112497,0.00005500087,0.0001028766,0.0003218758,0.0000140236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002628298,"about_ca_system_score_gemma":0.001660194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007124153,"about_ca_topic_score_gemma":0.00003770422,"domain_scores_codex":[0.9970078,0.00035072,0.001601629,0.0003141249,0.0003272014,0.0003985441],"domain_scores_gemma":[0.9978776,0.0002042089,0.001190037,0.000279243,0.0002852164,0.0001636829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00004606558,0.01283577,0.0009797426,0.02492128,0.001166774,0.5813392,0.00006094961,4.895992e-7,0.000004755275,0.0009744414,0.001381911,0.3762886],"study_design_scores_gemma":[0.01483077,0.0003338461,0.0001213607,0.06228315,0.003365962,0.4631377,0.00005997635,0.000003484376,0.0004553157,0.00005677025,0.4550249,0.0003267695],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04274818,0.9561073,0.00002580973,0.00006162727,0.0002836915,0.0004170849,0.00004172918,0.000006949296,0.0003076123],"genre_scores_gemma":[0.01043665,0.988443,0.0007065525,0.0001378561,0.00007321276,0.00002707817,0.00006886002,0.00006018304,0.00004660446],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.453643,"threshold_uncertainty_score":0.9999419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864777967318353,"score_gpt":0.3013110141533433,"score_spread":0.2826632344801598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}