{"id":"W3195042026","doi":"10.3389/fneur.2021.694329","title":"Methodological Issues in Randomized Clinical Trials for Prodromal Alzheimer's and Parkinson's Disease","year":2021,"lang":"en","type":"review","venue":"Frontiers in Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hotchkiss Brain Institute; Impact; University of Calgary","funders":"Hotchkiss Brain Institute, University of Calgary","keywords":"Clinical trial; Disease; Medicine; Prodromal Stage; Biomarker; Parkinson's disease; Population; Clinical research; Randomized controlled trial; Intensive care medicine; Dementia; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.5179116,0.001826586,0.01011783,0.002598853,0.001463727,0.007517149,0.00629263,0.007676209,0.004996668],"category_scores_gemma":[0.6377364,0.001727305,0.006584698,0.004971139,0.006900423,0.00630397,0.003479694,0.007776753,0.001192059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005225269,"about_ca_system_score_gemma":0.01247383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001547123,"about_ca_topic_score_gemma":0.001638324,"domain_scores_codex":[0.3089753,0.6107063,0.05033936,0.0103527,0.01857271,0.001053639],"domain_scores_gemma":[0.2565278,0.6908224,0.02057934,0.01801787,0.0128901,0.001162529],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.01405289,0.0003688377,0.003573808,0.2472978,0.02631609,0.0002893326,0.001622493,0.004244796,0.0006103218,0.1034049,0.02700321,0.5712156],"study_design_scores_gemma":[0.03454816,0.005828952,0.008396009,0.2515313,0.02862489,0.0008375875,0.001040843,0.009674568,0.00188049,0.3915209,0.2656412,0.0004751354],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003210473,0.7903977,0.1194349,0.03769165,0.01873033,0.02205204,0.001180712,0.00038941,0.006912706],"genre_scores_gemma":[0.1632831,0.2295761,0.3844539,0.05771071,0.01040869,0.1502732,0.001126203,0.0005189142,0.002649158],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4820884,"threshold_uncertainty_score":0.5945008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3982390472141197,"score_gpt":0.5111807835824521,"score_spread":0.1129417363683324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}