{"id":"W3195063565","doi":"10.1128/mbio.01920-21","title":"HIV-1 Vpu Promotes Phagocytosis of Infected CD4 <sup>+</sup> T Cells by Macrophages through Downregulation of CD47","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"CD47; Phagocytosis; Biology; Cell biology; Virology; Macrophage; Immune system; Cell; Tetherin; Downregulation and upregulation; Virus; Microbiology; Viral replication; Immunology; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001841061,0.0002574238,0.0002677826,0.0002568568,0.0002219685,0.0005588508,0.0001617766,0.0002612384,0.001528828],"category_scores_gemma":[0.0001467168,0.0001795047,0.0002963027,0.0001157768,0.0003459128,0.0001919577,0.0002810653,0.0006578797,0.0004736488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003181345,"about_ca_system_score_gemma":0.0002471471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004949109,"about_ca_topic_score_gemma":0.0005406744,"domain_scores_codex":[0.9997988,0.0000500585,0.00001217181,0.0000254888,0.00003691269,0.00007657845],"domain_scores_gemma":[0.9999154,0.00002264765,0.0000174517,0.0000114852,0.00001054649,0.00002261112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003715007,0.000070859,0.0003232236,0.00005233831,0.000004952318,0.00008769198,0.00002215309,0.00007354108,0.9962606,0.0002918593,0.0001651553,0.00227601],"study_design_scores_gemma":[0.00002840586,0.0004728918,0.007087409,0.00001215995,0.000008795789,0.0003728172,0.00005383836,0.001512573,0.9877116,0.0001679712,0.002565909,0.000005578316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941195,0.002630134,0.0009985686,0.0001515549,0.00004673121,0.0000144199,0.00009249789,0.00007206017,0.001874513],"genre_scores_gemma":[0.995542,0.0008789451,0.001066505,0.00005092936,0.00002128069,0.00002396244,0.0001399254,0.00002126847,0.002255228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001528828,"threshold_uncertainty_score":0.005114436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009830107878363649,"score_gpt":0.2265638781077274,"score_spread":0.2167337702293638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}