{"id":"W3195118973","doi":"10.21203/rs.3.rs-817941/v1","title":"Design, Synthesis, Physicochemical, Drug-likeness Properties of Quercetin Derivatives and Their Effect On MCF-7 Cell Line and Free Radicals","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Free Radicals and Antioxidants","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal College of Physicians and Surgeons of Canada","funders":"JSS College of Pharmacy","keywords":"Chemistry; DPPH; Docking (animal); MCF-7; Protein Data Bank (RCSB PDB); Cytotoxicity; Antioxidant; Quercetin; Radical; In vivo; In vitro; Hydrogen peroxide; Enzyme; Stereochemistry; Biochemistry; Combinatorial chemistry; Cancer cell; Cancer; Human breast; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001241295,0.0001916591,0.0001459114,0.0001972493,0.0001214967,0.0001698209,0.0002192122,0.000225866,0.0009370199],"category_scores_gemma":[0.0001035326,0.00009728652,0.0002276497,0.0001710723,0.0001142594,0.0001926385,0.00008764923,0.0002495155,0.0002438289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002306751,"about_ca_system_score_gemma":0.0001636554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007456921,"about_ca_topic_score_gemma":0.001407083,"domain_scores_codex":[0.9999499,0.000009399175,0.00000342367,0.0000106336,0.00001851391,0.000008082174],"domain_scores_gemma":[0.999953,0.000005093122,0.00001572462,0.000004236576,0.00001429965,0.000007601362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009271486,0.00005927998,0.0002275069,0.0001421004,0.00001337476,0.00007760296,0.00001748522,0.0007173286,0.9929662,0.0002630131,0.00007882322,0.005344625],"study_design_scores_gemma":[0.00004416899,0.001303312,0.001907114,0.00001061809,0.0000471315,0.0001796598,0.00002188574,0.001175939,0.9887968,0.00008237143,0.006415461,0.00001546048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760486,0.007976171,0.0118378,0.0003137197,0.00005527864,0.0001989705,0.0006033978,0.00007348863,0.002892521],"genre_scores_gemma":[0.9824622,0.002638765,0.01136666,0.00008980036,0.000008955963,0.00005400705,0.0003912129,0.00001167283,0.002976773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009370199,"threshold_uncertainty_score":0.003134608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04886366029794996,"score_gpt":0.3087090772906648,"score_spread":0.2598454169927149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}