{"id":"W3195126148","doi":"10.1038/s41541-021-00364-x","title":"Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers","year":2021,"lang":"en","type":"article","venue":"npj Vaccines","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Horizon 2020 Framework Programme; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; European Commission; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Adjuvant; Trimer; Immunogenicity; Nanoparticle; Liposome; Antibody; Chemistry; Antibody response; Cross-presentation; Biophysics; Nanotechnology; Immunology; Materials science; Biology; Biochemistry; Antigen presentation; In vitro; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006299363,0.0000668131,0.0001666284,0.00005411197,0.00003945838,0.000003016365,0.0000533428,0.00004497233,0.0008366216],"category_scores_gemma":[0.00009376166,0.00005376274,0.00003233139,0.000104466,0.00006096534,0.00006799582,0.00007618418,0.00004945637,0.00008169598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009070745,"about_ca_system_score_gemma":0.00005103352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006216277,"about_ca_topic_score_gemma":0.00004198972,"domain_scores_codex":[0.9994377,0.0001109299,0.0001575755,0.0001335876,0.00002955657,0.0001306134],"domain_scores_gemma":[0.9995848,0.0001107745,0.00005913722,0.0001055437,0.0001213445,0.0000183842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003822219,0.0002713585,0.1843596,0.00004566957,0.0003177613,0.00001548604,0.00146877,0.000001855121,0.7877251,0.00008908011,0.004800045,0.02052309],"study_design_scores_gemma":[0.002351571,0.0001958555,0.1631077,0.00001886215,0.00003163619,0.00001359459,0.001076311,0.000002528916,0.831614,0.00003637426,0.001504761,0.0000468158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967475,0.00212115,0.00001581889,0.0001244789,0.0001206213,0.0001019012,0.0000913695,0.000007669702,0.0006694771],"genre_scores_gemma":[0.9968342,0.0002047849,0.00009380304,0.00001087724,0.000004944179,0.000006985594,0.00009096896,0.000004058893,0.002749331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0438889,"threshold_uncertainty_score":0.916042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713393009112022,"score_gpt":0.2956482195555664,"score_spread":0.2785142894644462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}