{"id":"W3195126148","doi":"10.1038/s41541-021-00364-x","title":"Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers","year":2021,"lang":"en","type":"article","venue":"npj Vaccines","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Horizon 2020 Framework Programme; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; European Commission; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Adjuvant; Trimer; Immunogenicity; Nanoparticle; Liposome; Antibody; Chemistry; Antibody response; Cross-presentation; Biophysics; Nanotechnology; Immunology; Materials science; Biology; Biochemistry; Antigen presentation; In vitro; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003073563,0.0002440073,0.0002365843,0.0001660032,0.00006826691,0.0002830394,0.0001240909,0.000183104,0.000520213],"category_scores_gemma":[0.000297093,0.0001005054,0.0001273934,0.00006595572,0.0001501425,0.0002413264,0.0001868511,0.0002573539,0.0001177855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001335756,"about_ca_system_score_gemma":0.0001762063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001516436,"about_ca_topic_score_gemma":0.0003222536,"domain_scores_codex":[0.9998891,0.00003573445,0.000008675167,0.00001315545,0.00002034796,0.0000328265],"domain_scores_gemma":[0.9998958,0.00005042614,0.00001442467,0.000005139788,0.00001470316,0.00001949297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002593112,0.0000729021,0.0002864405,0.00005289144,0.000005394191,0.00002965026,0.00001147809,0.0003216951,0.9962345,0.00007298956,0.00001733386,0.002635533],"study_design_scores_gemma":[0.00003115612,0.001101376,0.001299136,0.000008796068,0.00002499394,0.0001153317,0.00002414534,0.002204938,0.9944243,0.0000743331,0.0006872922,0.000004175362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997869,0.0006283006,0.0008974801,0.00003486016,0.000009479205,0.00002008513,0.00001812265,0.00001437553,0.0005081458],"genre_scores_gemma":[0.9971039,0.0004328644,0.001886156,0.00004241932,0.000009617163,0.00001420476,0.00003501422,0.000008257765,0.0004674526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000520213,"threshold_uncertainty_score":0.001740217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713393009112022,"score_gpt":0.2956482195555664,"score_spread":0.2785142894644462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}