{"id":"W3195130348","doi":"10.1126/sciimmunol.abl4340","title":"Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths","year":2021,"lang":"en","type":"article","venue":"Science Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":631,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; BC Children's Hospital; University of British Columbia","funders":"NIH Clinical Center; National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Human Genome Research Institute; Agencia Estatal de Investigación; European Regional Development Fund; Instituto de Salud Carlos III; Biomedical Advanced Research and Development Authority; National Institutes of Health; Sorbonne Université; Instituto Colombiano de Crédito Educativo y Estudios Técnicos en el Exterior; Ipsen; Hellenic Foundation for Research and Innovation; Vlaamse regering; Regione Lombardia; Agentura Pro Zdravotnický Výzkum České Republiky; Uniformed Services University of the Health Sciences; Mutuelle Générale de l'Education Nationale; Medical Research Council; Tartu Ülikool; Università degli Studi di Brescia; Karadeniz Teknik Üniversitesi; Université de Bordeaux; Università degli Studi di Pavia; Howard Hughes Medical Institute; Meath Foundation; NHLBI Division of Intramural Research; University of Hong Kong; Al Jalila Foundation; Universitair Ziekenhuis Gent; Universiteit Gent; Shahid Beheshti University of Medical Sciences; CSL Behring; Chang Gung University; Fonds Wetenschappelijk Onderzoek; Università degli Studi di Milano-Bicocca; University of New South Wales; KU Leuven; Fondation pour la Recherche Médicale; Semmelweis Egyetem; Eesti Teadusagentuur; Universidade de São Paulo; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; University of Sharjah; Jeffrey Modell Foundation; National Health and Medical Research Council; Fondation du Souffle; Fisher Center for Alzheimer's Research Foundation; Assistance publique-Hôpitaux de Paris; Agence Nationale de la Recherche; Institut des maladies génétiques Imagine; Fudan University; Novo Nordisk Fonden; Celldex Therapeutics; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS); Japan Agency for Medical Research and Development; Croucher Foundation; Michael Smith Health Research BC; Georgia Clinical and Translational Science Alliance; Yale University; National Center for Advancing Translational Sciences; Mercatus Center, George Mason University; Da Volterra; JPB Foundation; Université de Bourgogne; Chang Gung Medical Foundation; Fondation de France; Sanofi; Irving Medical Center, Columbia University; Fondazione IRCCS Policlinico San Matteo; Fondation Bettencourt Schueller; George Mason University; Ministerio de Ciencia e Innovación; St. Giles Foundation","keywords":"Autoantibody; Coronavirus disease 2019 (COVID-19); Virology; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Immunology; Coronavirus Infections; Neutralizing antibody; Biology; Antibody; Medicine; Disease; Outbreak; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001239111,0.0002749919,0.0002118151,0.0004732585,0.0002969851,0.0002620651,0.0001260092,0.0002527326,0.004136085],"category_scores_gemma":[0.0004832736,0.0001224139,0.0001394293,0.0003475369,0.0001833928,0.0001690859,0.0002254511,0.0002690243,0.0009200769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000144116,"about_ca_system_score_gemma":0.0001171942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004385592,"about_ca_topic_score_gemma":0.004104768,"domain_scores_codex":[0.9998305,0.00002056117,0.00001191629,0.00003170321,0.00005097884,0.00005432065],"domain_scores_gemma":[0.999775,0.0000219123,0.0001084226,0.0000109211,0.00003693185,0.00004682196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000101746,0.00004049833,0.983823,0.00003343361,0.00003355778,0.0003192569,0.0001052207,0.00001543224,0.004143244,0.00002544439,0.001160114,0.01019905],"study_design_scores_gemma":[0.0000032306,0.00009222747,0.9965799,0.00001821923,0.0000184376,0.0008988155,0.0001572617,0.00002544672,0.0003220661,0.00002130373,0.001860493,0.000002557275],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941262,0.002198061,0.0001363474,0.0001028482,0.000033155,0.00001074226,0.000960756,0.00002771203,0.00240402],"genre_scores_gemma":[0.9958961,0.001148256,0.00009769596,0.0001868844,0.00005056127,0.000009908252,0.0008054492,0.000003093611,0.00180211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004385592,"threshold_uncertainty_score":0.01383656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05686671139286932,"score_gpt":0.396227218089239,"score_spread":0.3393605066963697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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