{"id":"W3195130348","doi":"10.1126/sciimmunol.abl4340","title":"Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths","year":2021,"lang":"en","type":"article","venue":"Science Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":631,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; BC Children's Hospital; University of British Columbia","funders":"NIH Clinical Center; National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Human Genome Research Institute; Agencia Estatal de Investigación; European Regional Development Fund; Instituto de Salud Carlos III; Biomedical Advanced Research and Development Authority; National Institutes of Health; Sorbonne Université; Instituto Colombiano de Crédito Educativo y Estudios Técnicos en el Exterior; Ipsen; Hellenic Foundation for Research and Innovation; Vlaamse regering; Regione Lombardia; Agentura Pro Zdravotnický Výzkum České Republiky; Uniformed Services University of the Health Sciences; Mutuelle Générale de l'Education Nationale; Medical Research Council; Tartu Ülikool; Università degli Studi di Brescia; Karadeniz Teknik Üniversitesi; Université de Bordeaux; Università degli Studi di Pavia; Howard Hughes Medical Institute; Meath Foundation; NHLBI Division of Intramural Research; University of Hong Kong; Al Jalila Foundation; Universitair Ziekenhuis Gent; Universiteit Gent; Shahid Beheshti University of Medical Sciences; CSL Behring; Chang Gung University; Fonds Wetenschappelijk Onderzoek; Università degli Studi di Milano-Bicocca; University of New South Wales; KU Leuven; Fondation pour la Recherche Médicale; Semmelweis Egyetem; Eesti Teadusagentuur; Universidade de São Paulo; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; University of Sharjah; Jeffrey Modell Foundation; National Health and Medical Research Council; Fondation du Souffle; Fisher Center for Alzheimer's Research Foundation; Assistance publique-Hôpitaux de Paris; Agence Nationale de la Recherche; Institut des maladies génétiques Imagine; Fudan University; Novo Nordisk Fonden; Celldex Therapeutics; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS); Japan Agency for Medical Research and Development; Croucher Foundation; Michael Smith Health Research BC; Georgia Clinical and Translational Science Alliance; Yale University; National Center for Advancing Translational Sciences; Mercatus Center, George Mason University; Da Volterra; JPB Foundation; Université de Bourgogne; Chang Gung Medical Foundation; Fondation de France; Sanofi; Irving Medical Center, Columbia University; Fondazione IRCCS Policlinico San Matteo; Fondation Bettencourt Schueller; George Mason University; Ministerio de Ciencia e Innovación; St. Giles Foundation","keywords":"Autoantibody; Coronavirus disease 2019 (COVID-19); Virology; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Immunology; Coronavirus Infections; Neutralizing antibody; Biology; Antibody; Medicine; Disease; Outbreak; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007285221,0.00009511071,0.0003477915,0.0004577906,0.0000626421,0.00001913233,0.0002221785,0.0001026222,0.00001508663],"category_scores_gemma":[0.001955586,0.00008680237,0.00004376068,0.00110149,0.001092808,0.0001365883,0.0002579505,0.0001601141,0.000001878084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000103995,"about_ca_system_score_gemma":0.001627576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006476043,"about_ca_topic_score_gemma":0.0001366769,"domain_scores_codex":[0.9986545,0.00006735243,0.0002831025,0.0003257782,0.0002925314,0.0003766747],"domain_scores_gemma":[0.99888,0.0003366764,0.0001195756,0.000319653,0.0003086211,0.00003549395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001032695,0.0001009913,0.4017673,0.0001489467,0.0000351473,0.00002947379,0.001103667,0.000004158831,0.5945784,0.001569199,0.00006495036,0.0004945099],"study_design_scores_gemma":[0.001948826,0.000425906,0.6753684,0.000133063,0.00002927805,0.00005257361,0.001450848,0.0001859477,0.3059379,0.001025346,0.01332853,0.0001133604],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966761,0.001852869,0.00001953399,0.0007401061,0.0001290014,0.0003105885,0.00001709182,0.00001616138,0.0002384957],"genre_scores_gemma":[0.9972851,0.00008015602,0.0002256733,0.00232104,0.00001579045,0.00001546166,0.000003524282,0.000008415737,0.00004479478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2886405,"threshold_uncertainty_score":0.4026498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05686671139286932,"score_gpt":0.396227218089239,"score_spread":0.3393605066963697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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