{"id":"W3195166408","doi":"10.1097/j.pain.0000000000002450","title":"Validating a biosignature-predicting placebo pill response in chronic pain in the settings of a randomized controlled trial","year":2021,"lang":"en","type":"article","venue":"Pain","topic":"Pain Management and Placebo Effect","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Center for Complementary and Integrative Health; National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"Placebo; Medicine; Chronic pain; Randomized controlled trial; Placebo response; Analgesic; Anesthesia; Internal medicine; Physical therapy; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3736929,0.0002084606,0.001032312,0.0002908204,0.00009374297,0.00008418208,0.0003679465,0.000102228,0.00005308454],"category_scores_gemma":[0.4075204,0.000144275,0.0003282806,0.0009510918,0.00009696087,0.00009094082,0.00008081249,0.0004451697,0.000004191337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001136506,"about_ca_system_score_gemma":0.0001778449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004258276,"about_ca_topic_score_gemma":0.00003596992,"domain_scores_codex":[0.6719179,0.3245112,0.001428161,0.0006950675,0.0007771866,0.000670517],"domain_scores_gemma":[0.7656373,0.2336532,0.0003637614,0.0002953741,0.00002231188,0.00002808569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.862033,0.00009740724,0.0001388002,0.00008005241,0.00002198174,0.0001390181,0.001791913,0.000666215,0.1323408,0.0001956202,0.0002755714,0.002219585],"study_design_scores_gemma":[0.6460018,0.0001650076,0.000008391755,0.0002594009,0.00003123463,0.000001489182,0.0004937525,0.3457744,0.006715889,0.0002376274,0.0001827558,0.0001282384],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682909,0.0005899496,0.01415655,0.003545939,0.0002869356,0.01026463,0.000006952102,0.00009037909,0.002767816],"genre_scores_gemma":[0.9971316,0.00002353076,0.000125807,0.001602842,0.0001084496,0.0008098418,0.000004004627,0.00001607741,0.0001778788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3451082,"threshold_uncertainty_score":0.644915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556152772215992,"score_gpt":0.270405075620304,"score_spread":0.2548435478981441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}