{"id":"W3195219055","doi":"10.2217/fon-2021-0598","title":"Clinical Activity and Safety of the Anti-PD-1 Monoclonal Antibody Dostarlimab for Patients with Recurrent or Advanced dMMR Endometrial Cancer","year":2021,"lang":"en","type":"letter","venue":"Future Oncology","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University Health Centre","funders":"","keywords":"Medicine; Endometrial cancer; Internal medicine; Regimen; Oncology; Microsatellite instability; Clinical trial; Cancer; DNA mismatch repair; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008363131,0.0002376883,0.0007153869,0.0001981517,0.000140261,0.0004823952,0.0002229038,0.0004376691,0.004146267],"category_scores_gemma":[0.001453785,0.0001303225,0.0007253772,0.0001985066,0.0002326657,0.0004299396,0.0001580531,0.001074985,0.0005830331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005511761,"about_ca_system_score_gemma":0.0004365649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002776691,"about_ca_topic_score_gemma":0.001175898,"domain_scores_codex":[0.999738,0.0001359834,0.00002013233,0.00002845147,0.00004944047,0.00002789045],"domain_scores_gemma":[0.9996756,0.0001026491,0.00009938484,0.00001800776,0.0000261843,0.00007809834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2693299,0.005698963,0.0108919,0.003325436,0.001626048,0.0001800924,0.0001261942,0.002002048,0.01064803,0.0008343224,0.01760058,0.6777365],"study_design_scores_gemma":[0.4107063,0.4077544,0.08192235,0.001735949,0.003081776,0.001813365,0.0002275817,0.005185822,0.008444784,0.002478228,0.07654684,0.0001026453],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8950055,0.07690725,0.0006503951,0.002993089,0.0006406693,0.001072347,0.002479512,0.0001513232,0.0200999],"genre_scores_gemma":[0.9813596,0.01066148,0.0006642848,0.001551491,0.0002557539,0.0004387484,0.001502733,0.00001889116,0.003546977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004146267,"threshold_uncertainty_score":0.01387066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03426658383925036,"score_gpt":0.3826646853782454,"score_spread":0.3483981015389951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}