{"id":"W3195219055","doi":"10.2217/fon-2021-0598","title":"Clinical Activity and Safety of the Anti-PD-1 Monoclonal Antibody Dostarlimab for Patients with Recurrent or Advanced dMMR Endometrial Cancer","year":2021,"lang":"en","type":"letter","venue":"Future Oncology","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University Health Centre","funders":"","keywords":"Medicine; Endometrial cancer; Internal medicine; Regimen; Oncology; Microsatellite instability; Clinical trial; Cancer; DNA mismatch repair; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003068061,0.0004550722,0.00204376,0.0001579106,0.0001215213,0.00001102449,0.0002071554,0.001155421,0.0003758029],"category_scores_gemma":[0.000663431,0.0002317685,0.000461708,0.0006373246,0.0002836467,0.0000559271,0.0001700863,0.001615325,0.000001011503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004486345,"about_ca_system_score_gemma":0.001405339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007046356,"about_ca_topic_score_gemma":0.0001971398,"domain_scores_codex":[0.9969544,0.000476842,0.0007259301,0.0008111774,0.000550388,0.0004812962],"domain_scores_gemma":[0.9961227,0.001983647,0.0007982308,0.0004831216,0.0004715879,0.0001407011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1398218,0.003325699,0.1508655,0.001753962,0.003384616,0.0002879725,0.0000955588,0.000001086329,0.0001254545,0.00001242579,0.1207351,0.5795909],"study_design_scores_gemma":[0.0431709,0.008214966,0.1695774,0.0003883168,0.001348424,0.00001902712,0.00001697366,0.000002017385,0.00007086073,0.000008967295,0.7769375,0.0002446417],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5653217,0.00619318,0.00007076461,0.3932973,0.02140319,0.007865027,0.005069523,0.00005310878,0.0007262299],"genre_scores_gemma":[0.2609071,0.05021228,0.0135834,0.5219901,0.1298671,0.003129622,0.01332149,0.0007619886,0.006226983],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.6562024,"threshold_uncertainty_score":0.9451244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03426658383925036,"score_gpt":0.3826646853782454,"score_spread":0.3483981015389951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}