{"id":"W3195313686","doi":"10.1007/s00401-021-02362-8","title":"Early white matter pathology in the fornix of the limbic system in Huntington disease","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"National Health and Medical Research Council; National Institutes of Health; Vetenskapsrådet; Neuroscience Research Australia; Knut och Alice Wallenbergs Stiftelse; FightMND; Lunds Universitet; University of Sydney; National Institute on Alcohol Abuse and Alcoholism; National University of Singapore; University of New South Wales; Multiple Sclerosis Society; Michael Smith Health Research BC; Agency for Science, Technology and Research; National Multiple Sclerosis Society","keywords":"Fornix; Limbic system; White matter; Pathology; Myelin; Huntington's disease; Neuroscience; Biology; Medicine; Hippocampus; Central nervous system; Disease; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001270755,0.000407942,0.0002596227,0.0009303298,0.000246342,0.0002434964,0.0001382832,0.0002552818,0.001321695],"category_scores_gemma":[0.0001746021,0.0001593398,0.0001565031,0.0002989988,0.0003978257,0.0002011531,0.0002891156,0.0001761472,0.0001929642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084806,"about_ca_system_score_gemma":0.0001326662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001490458,"about_ca_topic_score_gemma":0.002822859,"domain_scores_codex":[0.9999264,0.000008189669,0.00000649993,0.00003070427,0.00001764458,0.00001046169],"domain_scores_gemma":[0.999882,0.00001455155,0.00005635379,0.00001214033,0.0000157539,0.00001917389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006935449,0.00004739316,0.05160974,0.0002188234,0.0001239466,0.002430807,0.0003485986,0.0001367803,0.9346719,0.0001434645,0.0001806854,0.009394157],"study_design_scores_gemma":[0.000009647298,0.0002171805,0.9572293,0.00001977331,0.00007622828,0.00554699,0.0001122682,0.0001844409,0.03541894,0.0001697468,0.001005224,0.00001027193],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960055,0.002151896,0.0008285813,0.00002441689,0.000007567715,0.00001284833,0.0002100651,0.00003008058,0.0007290374],"genre_scores_gemma":[0.996494,0.0009807047,0.0009123214,0.00003426562,0.00001197773,0.00001176254,0.0003977043,0.00001381485,0.001143493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001490458,"threshold_uncertainty_score":0.004421532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02138196634175829,"score_gpt":0.2342910616450537,"score_spread":0.2129090953032954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}