{"id":"W3195313686","doi":"10.1007/s00401-021-02362-8","title":"Early white matter pathology in the fornix of the limbic system in Huntington disease","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"National Health and Medical Research Council; National Institutes of Health; Vetenskapsrådet; Neuroscience Research Australia; Knut och Alice Wallenbergs Stiftelse; FightMND; Lunds Universitet; University of Sydney; National Institute on Alcohol Abuse and Alcoholism; National University of Singapore; University of New South Wales; Multiple Sclerosis Society; Michael Smith Health Research BC; Agency for Science, Technology and Research; National Multiple Sclerosis Society","keywords":"Fornix; Limbic system; White matter; Pathology; Myelin; Huntington's disease; Neuroscience; Biology; Medicine; Hippocampus; Central nervous system; Disease; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002956199,0.0002100522,0.0002500053,0.00008451568,0.0001120698,0.00007099236,0.0008648896,0.00005233213,0.00004413807],"category_scores_gemma":[0.001466233,0.0001254538,0.0001333315,0.0007671785,0.0002430329,0.00009372032,0.0004005808,0.0003386289,0.00004853004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001684554,"about_ca_system_score_gemma":0.00006489749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002646534,"about_ca_topic_score_gemma":0.000007941487,"domain_scores_codex":[0.9950078,0.003146992,0.0004174478,0.0007008718,0.0003320978,0.0003948617],"domain_scores_gemma":[0.998301,0.0004192725,0.0001866888,0.0009913507,0.00004469011,0.00005704664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003855802,0.0002496587,0.5028494,0.00004605479,3.771133e-7,0.001535292,0.0004312216,0.00008955238,0.4942752,0.0002981496,0.0001297027,0.00005684087],"study_design_scores_gemma":[0.0002461646,0.00005829391,0.8967741,0.00003486288,0.00001181895,0.00009649265,0.0001618942,0.00003085548,0.1022584,0.0001005404,0.0001169123,0.0001097595],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946383,0.00004071804,0.000004039131,0.003124425,0.0002851056,0.0004191986,0.0000380931,0.00002650018,0.001423658],"genre_scores_gemma":[0.9937684,0.0000139238,0.00001615248,0.005920088,0.00002978931,0.00008018356,0.000001545964,0.00002267735,0.0001472635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3939247,"threshold_uncertainty_score":0.5115859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02138196634175829,"score_gpt":0.2342910616450537,"score_spread":0.2129090953032954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}