{"id":"W3195361817","doi":"10.1093/brain/awab314","title":"Towards a comprehensive 3D mapping of tau progression in early Alzheimer’s disease","year":2021,"lang":"en","type":"letter","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Western University","funders":"","keywords":"Tangle; Neurofibrillary tangle; Neuroscience; Temporal lobe; Alzheimer's disease; Disease; Psychology; Human brain; Medicine; Pathology; Senile plaques; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007899455,0.000702562,0.001875416,0.001125545,0.002448094,0.002773133,0.002331848,0.03761197,0.003673312],"category_scores_gemma":[0.03445216,0.0006684434,0.001181044,0.0007916964,0.003100779,0.004464943,0.001701629,0.03556476,0.00633307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003092084,"about_ca_system_score_gemma":0.00357844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006158993,"about_ca_topic_score_gemma":0.009945856,"domain_scores_codex":[0.9956909,0.001373322,0.000695848,0.0004616379,0.001540026,0.0002382904],"domain_scores_gemma":[0.9706923,0.01862498,0.0006988983,0.0006911924,0.008090895,0.001201653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0000713764,0.00001936846,0.0002129758,0.000141914,0.0000142619,0.0005366104,0.0001118193,0.00005633902,0.0002752489,0.002204521,0.9685314,0.02782416],"study_design_scores_gemma":[0.0001255068,0.00008242852,0.0009887239,0.0007619485,0.00004670719,0.001886892,0.0002959402,0.0005637642,0.0004939788,0.022391,0.9722881,0.00007511159],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.0002273135,0.0072242,0.000678832,0.9463636,0.04418991,0.00001052852,0.00009849881,0.00005455653,0.001152415],"genre_scores_gemma":[0.004017779,0.009442523,0.001735804,0.8143638,0.165704,0.0000902324,0.0001136095,0.00008430654,0.004448098],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03761197,"threshold_uncertainty_score":0.04177678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06924280297632202,"score_gpt":0.3496155483592153,"score_spread":0.2803727453828933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}