{"id":"W3195378863","doi":"10.3390/nano11092154","title":"Design, Synthesis, and Cytotoxicity Assessment of [64Cu]Cu-NOTA-Terpyridine Platinum Conjugate: A Novel Chemoradiotherapeutic Agent with Flexible Linker","year":2021,"lang":"en","type":"article","venue":"Nanomaterials","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"Conjugate; Linker; Chemistry; Internalization; Cancer cell; Cytotoxicity; Cytotoxic T cell; Platinum; Stereochemistry; Moiety; Combinatorial chemistry; In vitro; Biophysics; Biochemistry; Cancer; Cell; Biology; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001944398,0.0003300948,0.0002913892,0.0001794414,0.0001462668,0.0002569036,0.0003192986,0.0003573396,0.0004597332],"category_scores_gemma":[0.0001584355,0.000205535,0.000195078,0.0002241924,0.0001902295,0.0001968807,0.0001346396,0.0002629845,0.000332552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004562309,"about_ca_system_score_gemma":0.0003527324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000576567,"about_ca_topic_score_gemma":0.0005540752,"domain_scores_codex":[0.999881,0.00001673314,0.00001530138,0.00003453243,0.0000376457,0.00001482394],"domain_scores_gemma":[0.999855,0.00001074209,0.00005858346,0.00001625089,0.00003433555,0.00002493264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006759605,0.00003349698,0.00009497889,0.00006741367,0.000004675394,0.00005405884,0.00001468137,0.0003829088,0.9964294,0.0001736408,0.00002887929,0.002648372],"study_design_scores_gemma":[0.0000123185,0.0003151213,0.000389349,0.000002135634,0.000009160715,0.0001096028,0.000002586573,0.0007617309,0.9965391,0.00001359009,0.001840713,0.000004587096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588031,0.002230984,0.03479934,0.0001364938,0.00004287974,0.0005683361,0.0003744358,0.0001918785,0.002852703],"genre_scores_gemma":[0.9526039,0.001508967,0.04074681,0.00006429682,0.00001796638,0.0002940809,0.0004739023,0.00004398832,0.004246107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000576567,"threshold_uncertainty_score":0.003310204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05663517661088704,"score_gpt":0.3415516930251768,"score_spread":0.2849165164142898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}