{"id":"W3195387519","doi":"10.1101/2021.08.20.456807","title":"The ataxia protein sacsin is required for integrin trafficking and synaptic organization","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Cell biology; Phenotype; Ataxia; Biology; Spinocerebellar ataxia; Synaptic vesicle; Microtubule; Cell adhesion; Cerebellum; Neuroscience; Cell; Vesicle; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124758,0.000363987,0.0001723847,0.0002587124,0.0002273776,0.0003488066,0.0001414839,0.0003204791,0.001669289],"category_scores_gemma":[0.0001334787,0.0001493548,0.000174118,0.0001462959,0.0001754198,0.0001503433,0.0002710362,0.0003153807,0.0009254417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002777769,"about_ca_system_score_gemma":0.0001928123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010067,"about_ca_topic_score_gemma":0.001458059,"domain_scores_codex":[0.9999005,0.00001167401,0.00001132246,0.00002246627,0.00003933418,0.00001470363],"domain_scores_gemma":[0.9998882,0.00001280687,0.00003834817,0.00001105615,0.00001464042,0.00003489052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000841738,0.00000826272,0.0007423128,0.00003053085,0.000007009972,0.000277288,0.00001276871,0.00007421189,0.9971713,0.0002487873,0.0001933317,0.00115001],"study_design_scores_gemma":[0.00003732442,0.0001088242,0.0479141,0.00002089643,0.00002686691,0.002397433,0.00006407144,0.004540322,0.9322475,0.0003421913,0.01229061,0.000009891599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917803,0.001487654,0.003018929,0.0001644336,0.00005787165,0.000007723324,0.0008773598,0.0001629844,0.002442836],"genre_scores_gemma":[0.9936766,0.0003270782,0.001293467,0.00003019708,0.00001127526,0.000006494933,0.00129412,0.00002212889,0.003338648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001669289,"threshold_uncertainty_score":0.0055843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0227060502467691,"score_gpt":0.2318647409286334,"score_spread":0.2091586906818643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}