{"id":"W3195407713","doi":"10.1016/j.jconrel.2021.08.029","title":"Polymeric and lipid nanoparticles for delivery of self-amplifying RNA vaccines","year":2021,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada); Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Engineering and Physical Sciences Research Council; European Commission; University of British Columbia; Department of Health and Social Care","keywords":"Immunogenicity; Biology; RNA; Virology; Vaccination; Microbiology; Antigen; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000173097,0.00009916168,0.0003498179,0.00005025446,0.00004163157,0.00001941128,0.00008681902,0.00005732671,0.00001055034],"category_scores_gemma":[0.0002179567,0.00007792993,0.000230751,0.00004967873,0.00001855781,0.000008472083,0.00003437473,0.00005619167,4.843569e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000509301,"about_ca_system_score_gemma":0.000180577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002979397,"about_ca_topic_score_gemma":0.00000360921,"domain_scores_codex":[0.9991733,0.00005698386,0.000429583,0.0001156127,0.00009214856,0.0001323307],"domain_scores_gemma":[0.9989198,0.0000681116,0.0003249967,0.0001185746,0.0004811008,0.00008738846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002213956,0.00009995783,0.0005549137,0.00003308498,0.0003149009,0.00001399061,0.0000310317,0.00003641459,0.9878448,0.00001517386,0.0004790363,0.008362775],"study_design_scores_gemma":[0.008993707,0.0007936065,0.0005162813,0.00005418666,0.000224636,0.0001460913,0.0001937386,0.0002420301,0.985536,0.00005672411,0.003131153,0.0001118786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799559,0.01836573,0.001079083,0.0002617006,0.0001764854,0.00009615138,0.000005924321,0.000002098286,0.00005690751],"genre_scores_gemma":[0.9955056,0.002848442,0.0009272893,0.0002221741,0.0003322511,0.000004746258,0.000003635227,0.000009922011,0.0001459231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0155497,"threshold_uncertainty_score":0.317789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008064316500508309,"score_gpt":0.2397330877415624,"score_spread":0.2316687712410541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}