{"id":"W3195433712","doi":"10.1002/jev2.12132","title":"Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum","year":2021,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Endosome; Cell biology; Extracellular vesicle; Endoplasmic reticulum; Cancer cell; Intracellular; Biology; Chemistry; Biochemistry; Cancer; Microvesicles","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005686327,0.0001929128,0.0001875383,0.0001324768,0.00010907,0.0002060801,0.0001424422,0.0002075618,0.0009594438],"category_scores_gemma":[0.0000953607,0.00005263666,0.0001202804,0.0001195818,0.0001514969,0.00009739195,0.0001006635,0.0002788592,0.0002243779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002108206,"about_ca_system_score_gemma":0.0001743732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142526,"about_ca_topic_score_gemma":0.001179613,"domain_scores_codex":[0.9999017,0.00002004561,0.00001099455,0.00001436375,0.00001958234,0.00003341249],"domain_scores_gemma":[0.9999452,0.00001497336,0.00001003649,0.000009916454,0.000006643012,0.00001325743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001257102,0.00003771695,0.0001135209,0.00003508031,0.000004128559,0.00002939181,0.000009631521,0.00008928245,0.9974408,0.0001087844,0.0000649551,0.001940934],"study_design_scores_gemma":[0.00001531185,0.0004282174,0.002138993,0.000004499087,0.000009553805,0.00009765852,0.0000119855,0.0008846188,0.9947363,0.00002311222,0.001647206,0.000002503023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947264,0.00187656,0.001167538,0.00006562654,0.00002886663,0.00001997044,0.0001596786,0.00007743256,0.001877979],"genre_scores_gemma":[0.9980515,0.0005414399,0.0004194272,0.00001625969,0.000004993637,0.000009096816,0.0001144577,0.000005691171,0.0008370759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001142526,"threshold_uncertainty_score":0.00320971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005115584054585146,"score_gpt":0.214493915340003,"score_spread":0.2093783312854179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}