{"id":"W3195519455","doi":"10.1097/cji.0000000000000386","title":"Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers","year":2021,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovative Targeting Solutions (Canada)","funders":"","keywords":"Medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006070456,0.0002411827,0.0006007682,0.0002574346,0.0001471247,0.0000831845,0.0002338414,0.0001724614,0.001228746],"category_scores_gemma":[0.00006523015,0.000204577,0.0006723205,0.0004423197,0.0001081103,0.0001359193,0.00002280918,0.0006670063,0.000009979553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008769231,"about_ca_system_score_gemma":0.002538533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001173672,"about_ca_topic_score_gemma":0.00001226789,"domain_scores_codex":[0.997739,0.0001739565,0.0005727162,0.0002464786,0.0007956721,0.0004721562],"domain_scores_gemma":[0.9965183,0.0001924364,0.0006500471,0.0003124453,0.002156863,0.0001699665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006066801,0.0004281861,0.0002887374,0.00002685453,0.001699186,0.0003485295,0.001305316,0.00008677077,0.8801858,0.00002242969,0.001231959,0.1083094],"study_design_scores_gemma":[0.01548173,0.004833286,0.003614572,0.0001563827,0.0003180099,0.002774325,0.001661425,0.0002024244,0.9137691,0.0006406253,0.05627085,0.0002772188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9324292,0.04036023,0.007213967,0.006594692,0.001638344,0.001350172,0.00005521964,0.0000373988,0.01032079],"genre_scores_gemma":[0.9441322,0.02215353,0.004069146,0.005271109,0.001485843,0.00002731714,0.00002351447,0.0001783588,0.022659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1080322,"threshold_uncertainty_score":0.9996843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01909053515891886,"score_gpt":0.3282256471747907,"score_spread":0.3091351120158719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}