{"id":"W3195595411","doi":"10.2217/fon-2021-0608","title":"Brigatinib Versus Alectinib in Crizotinib-Resistant Advanced Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer (ALTA-3)","year":2021,"lang":"en","type":"article","venue":"Future Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Alectinib; Crizotinib; Medicine; Anaplastic lymphoma kinase; Lung cancer; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001129899,0.0006741626,0.001461802,0.000318224,0.0002426029,0.0008206575,0.000639518,0.0008648472,0.007363842],"category_scores_gemma":[0.001432661,0.0002686208,0.001265487,0.0003195376,0.0004690858,0.0007041858,0.0002700522,0.002157313,0.0008927461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007358894,"about_ca_system_score_gemma":0.001033135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150946,"about_ca_topic_score_gemma":0.004593046,"domain_scores_codex":[0.999632,0.0001856311,0.00003455656,0.00004251645,0.00002567889,0.00007969928],"domain_scores_gemma":[0.9994987,0.0001373741,0.0001320764,0.00002927059,0.00002503963,0.0001775331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9531171,0.004311066,0.0003751863,0.000543043,0.000488923,0.0000355307,0.00004653789,0.0004751127,0.003512315,0.0001684263,0.001419753,0.03550695],"study_design_scores_gemma":[0.744004,0.2422606,0.004756502,0.0001385461,0.001030428,0.0001095142,0.00006775046,0.001547587,0.002263249,0.0004448513,0.003347294,0.00002969666],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811254,0.007983806,0.0003298809,0.0009805149,0.0007336765,0.001800829,0.001040355,0.0001360158,0.005869516],"genre_scores_gemma":[0.9875448,0.003439175,0.0007335635,0.0006447365,0.0002525206,0.001428795,0.0008072986,0.00001952362,0.005129489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007363842,"threshold_uncertainty_score":0.02463454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082077063560054,"score_gpt":0.3412207235650259,"score_spread":0.3303999529294254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}