{"id":"W3195599057","doi":"10.1016/j.ydbio.2021.08.004","title":"Protein fucosylation is required for Notch dependent vascular integrity in zebrafish","year":2021,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Japan Society for the Promotion of Science; Natural Sciences and Engineering Research Council of Canada; Memorial University of Newfoundland","keywords":"Fucosylation; Zebrafish; Biology; Cell biology; Mural cell; Notch signaling pathway; Mutant; Phenotype; Fucose; Endothelial stem cell; Signal transduction; Genetics; In vitro; Gene; Glycoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00039609,0.0001382113,0.0001636029,0.00006722083,0.00007558712,0.000018427,0.0002197172,0.0003017494,0.000113982],"category_scores_gemma":[0.0005904381,0.0001379716,0.00007578638,0.0002195376,0.0001077507,0.000005384782,0.0002374786,0.0001537952,0.00004118603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009949095,"about_ca_system_score_gemma":0.0004738673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003701866,"about_ca_topic_score_gemma":0.0003880154,"domain_scores_codex":[0.9985442,0.00009663858,0.0003030375,0.0005529966,0.0001293607,0.0003737526],"domain_scores_gemma":[0.9994274,0.00002796767,0.00005035162,0.0002288904,0.0001530938,0.000112302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004771426,0.0001152295,0.003203011,0.00001859596,0.00004464959,0.000002928503,0.00003685436,1.567175e-7,0.9852141,0.0005143824,0.00106714,0.009735242],"study_design_scores_gemma":[0.000979207,0.0001001469,0.00690649,0.00001390229,0.00000342744,0.000009828153,0.0001005127,0.00003227251,0.8856913,0.001723598,0.1042493,0.0001899632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820804,0.0002572665,0.01408417,0.001917661,0.000073572,0.0008204558,0.0001210712,0.00001601503,0.0006293753],"genre_scores_gemma":[0.979667,0.00006604478,0.01597559,0.0008429997,0.00008807016,0.000714112,0.002144467,0.00001770376,0.0004840232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1031822,"threshold_uncertainty_score":0.562632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486840058549996,"score_gpt":0.3098281128105589,"score_spread":0.2849597122250589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}