{"id":"W3195602324","doi":"10.1101/2021.08.20.457162","title":"Super-enhancer signature reveals key mechanisms associated with resistance to non-alcoholic steatohepatitis in humans with obesity","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval","funders":"Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Bausch Health; Novo Nordisk; Université Laval; American Diabetes Association","keywords":"Enhancer; Biology; Steatohepatitis; Phenotype; Transcription factor; Genetics; Epigenetics; Gene; Computational biology; Fatty liver; Disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001533369,0.0001315014,0.000208736,0.0002448301,0.00008898728,0.0001809516,0.00007177205,0.0001578507,0.00272717],"category_scores_gemma":[0.0002309282,0.0001149864,0.0002210108,0.000195804,0.0001274222,0.00008431287,0.0001809711,0.0003065256,0.0003267736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006912968,"about_ca_system_score_gemma":0.0000815547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003494588,"about_ca_topic_score_gemma":0.0005533239,"domain_scores_codex":[0.9999325,0.000008882016,0.000002711684,0.00002946096,0.00001399575,0.00001245356],"domain_scores_gemma":[0.999899,0.00002423534,0.00003330529,0.00001580149,0.000009660655,0.00001797395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002096475,0.00008670214,0.1487657,0.0002481705,0.0001982806,0.0005885314,0.0002826075,0.0009332976,0.8143205,0.001414579,0.001584827,0.02948024],"study_design_scores_gemma":[0.00006512497,0.0002433314,0.9280965,0.00003207035,0.0001474848,0.001716522,0.0001810751,0.005254881,0.05477092,0.002703217,0.006763268,0.00002555755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869986,0.000845032,0.007246263,0.0001856733,0.00002638061,0.0000136137,0.003007749,0.0001548788,0.00152184],"genre_scores_gemma":[0.9927308,0.0002514843,0.003009518,0.0001058391,0.00001870159,0.00001762326,0.002363055,0.00006572258,0.001437294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00272717,"threshold_uncertainty_score":0.009123325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009503469684019078,"score_gpt":0.2176839162625467,"score_spread":0.2081804465785276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}