{"id":"W3195622434","doi":"10.1097/md.0000000000026999","title":"The neuromuscular and multisystem features of RYR1-related malignant hyperthermia and rhabdomyolysis","year":2021,"lang":"en","type":"article","venue":"Medicine","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Thomas Hospital; University Health Network","funders":"Radboud Universitair Medisch Centrum; Radboud Universiteit","keywords":"RYR1; Medicine; Malignant hyperthermia; Rhabdomyolysis; Magnetic resonance imaging; Disease; Intensive care medicine; Internal medicine; Physical medicine and rehabilitation; Physical therapy; Pathology; Radiology; Receptor; Ryanodine receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004066553,0.0002987919,0.0004206452,0.0003223326,0.0001779208,0.0001719038,0.0001927925,0.0002546988,0.002930114],"category_scores_gemma":[0.000638038,0.00007704664,0.0002250028,0.0002064382,0.000213192,0.0002094193,0.0003499712,0.0002408164,0.0002852385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001790066,"about_ca_system_score_gemma":0.0002098697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003035528,"about_ca_topic_score_gemma":0.0004133374,"domain_scores_codex":[0.9997352,0.00008937617,0.00003211601,0.00005582493,0.00004757029,0.00004006064],"domain_scores_gemma":[0.9995987,0.00009636469,0.0001852509,0.00001814781,0.0000308149,0.00007063752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001668694,0.0004363674,0.8907024,0.0009199894,0.0001258573,0.02864084,0.0004617319,0.0003251234,0.0212444,0.0004190927,0.001373473,0.05368199],"study_design_scores_gemma":[0.00005377054,0.001023848,0.9424955,0.00009601142,0.00004262306,0.0528392,0.000140819,0.0001551254,0.001320464,0.0001121333,0.001706198,0.00001428959],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989815,0.004487374,0.0009009939,0.0002031683,0.0000232173,0.0002857404,0.0004698245,0.00002229739,0.003792288],"genre_scores_gemma":[0.9967089,0.0008778413,0.0009457708,0.0001494675,0.00004907518,0.0001351373,0.0002510624,0.000002442632,0.0008802981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002930114,"threshold_uncertainty_score":0.009802163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006021162401306746,"score_gpt":0.2167257784259653,"score_spread":0.2107046160246586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}