{"id":"W3195622434","doi":"10.1097/md.0000000000026999","title":"The neuromuscular and multisystem features of RYR1-related malignant hyperthermia and rhabdomyolysis","year":2021,"lang":"en","type":"article","venue":"Medicine","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Thomas Hospital; University Health Network","funders":"Radboud Universitair Medisch Centrum; Radboud Universiteit","keywords":"RYR1; Medicine; Malignant hyperthermia; Rhabdomyolysis; Magnetic resonance imaging; Disease; Intensive care medicine; Internal medicine; Physical medicine and rehabilitation; Physical therapy; Pathology; Radiology; Receptor; Ryanodine receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413172,0.00006216441,0.00009969652,0.00001543485,0.00006957626,0.000004835691,0.0000271939,0.00005904136,0.00001076576],"category_scores_gemma":[0.0001289054,0.00003661371,0.00002166927,0.00006285576,0.000112031,0.000001115144,0.0000314678,0.00003474355,3.28939e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001745432,"about_ca_system_score_gemma":0.00001050298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001328105,"about_ca_topic_score_gemma":0.00001259155,"domain_scores_codex":[0.99952,0.00005904746,0.0001274268,0.0001437509,0.00008294474,0.00006684872],"domain_scores_gemma":[0.99968,0.00002100377,0.00004614791,0.0001426828,0.00007516286,0.00003495768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005145626,0.00001254549,0.001682527,0.00004044558,0.00008114349,0.000008774037,0.0002084602,0.00001576614,0.9668639,0.0002806498,0.001580131,0.02917424],"study_design_scores_gemma":[0.00603297,0.0009870699,0.2656702,0.0002947454,0.0003008239,0.0009616497,0.004066603,0.002755013,0.4444042,0.000239221,0.2738515,0.0004359457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833854,0.01274725,0.0001623997,0.002882719,0.0003071028,0.00007432795,0.000001702795,0.000004899196,0.0004342327],"genre_scores_gemma":[0.9965156,0.001158566,0.00002360937,0.0001319109,0.0001224402,0.000003081166,0.00002634193,0.000006505701,0.00201194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5224596,"threshold_uncertainty_score":0.1493064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006021162401306746,"score_gpt":0.2167257784259653,"score_spread":0.2107046160246586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}