{"id":"W3195626778","doi":"10.1002/psp4.12683","title":"Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic study","year":2021,"lang":"en","type":"article","venue":"CPT Pharmacometrics & Systems Pharmacology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Alberta Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fondation Charles-Bruneau; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Oak Foundation; National Science Foundation","keywords":"Medicine; Busulfan; Hematopoietic stem cell transplantation; Dosing; Pharmacokinetics; Population; Transplantation; Internal medicine; NONMEM; Oncology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006295964,0.0004640166,0.0006759672,0.0001661744,0.0001495183,0.0005702127,0.0003490916,0.0003321223,0.000290227],"category_scores_gemma":[0.008692414,0.0001781337,0.0006171798,0.0003165733,0.0002450754,0.0003258984,0.000287192,0.000520928,0.00008728798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007608776,"about_ca_system_score_gemma":0.0009040862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002448548,"about_ca_topic_score_gemma":0.001033432,"domain_scores_codex":[0.9982673,0.0009734753,0.00006905673,0.0003420705,0.0003005569,0.00004750724],"domain_scores_gemma":[0.9964636,0.001673198,0.0008604412,0.0005281365,0.0003905915,0.00008405167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009685899,0.001322739,0.6047118,0.0001933034,0.002107619,0.0003763258,0.001213196,0.2114338,0.02415848,0.0009141047,0.002247603,0.141635],"study_design_scores_gemma":[0.001526511,0.01977373,0.6089616,0.00004310563,0.001629683,0.0009090375,0.0002758905,0.3392844,0.02102034,0.001029747,0.005439598,0.0001063792],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940553,0.0002387789,0.005245796,0.00004413588,0.000003934305,0.00003140074,0.0001922595,0.00004604521,0.000142309],"genre_scores_gemma":[0.9976134,0.0001219244,0.001823508,0.00002991724,0.000007144713,0.00001879475,0.0003347314,0.00001274186,0.0000377925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006295964,"threshold_uncertainty_score":0.03329664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0286474273532771,"score_gpt":0.3178178858974817,"score_spread":0.2891704585442046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}