{"id":"W3195636258","doi":"10.1111/bjh.17789","title":"Characterisation of immune checkpoints in Richter syndrome identifies LAG3 as a potential therapeutic target","year":2021,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"Snowdome Foundation; Peter MacCallum Cancer Centre","keywords":"Lymphoma; Immune checkpoint; Immune system; Cancer research; Follicular lymphoma; Context (archaeology); T cell; Immunohistochemistry; Immunology; Biology; Medicine; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001388993,0.0002141706,0.0001685826,0.0004047561,0.0000743953,0.0002089488,0.0001221075,0.0002372834,0.0007354155],"category_scores_gemma":[0.0002829598,0.00009397529,0.0002335789,0.0002123394,0.0002068453,0.0001537845,0.0001661376,0.0002398034,0.0001442641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002488844,"about_ca_system_score_gemma":0.00009660675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003922743,"about_ca_topic_score_gemma":0.0006591439,"domain_scores_codex":[0.9999385,0.00001071738,0.000007858683,0.00001537288,0.00001313729,0.0000144077],"domain_scores_gemma":[0.9998629,0.00004693902,0.00004546879,0.00001068373,0.00001015372,0.00002391496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001246995,0.00003770026,0.1042333,0.0001517412,0.00006606551,0.006194711,0.0001239349,0.001009031,0.8600051,0.00045583,0.0003404963,0.0261352],"study_design_scores_gemma":[0.0001905868,0.001604947,0.614682,0.00007513075,0.0002442068,0.04839027,0.0004393606,0.009491333,0.3153163,0.001580972,0.007949498,0.00003552403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968891,0.001142439,0.001194622,0.0001057682,0.000004538661,0.0000115142,0.0002121148,0.00002974306,0.0004102521],"genre_scores_gemma":[0.9986388,0.0003183771,0.0006668905,0.00004615947,0.000004405465,0.000008025125,0.0001808604,0.000004776271,0.0001316921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007354155,"threshold_uncertainty_score":0.002460182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00913646912819125,"score_gpt":0.2597497397531262,"score_spread":0.2506132706249349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}