{"id":"W3195711664","doi":"10.2147/cmar.s324203","title":"Transcriptome Signature of Immune Cells Post Reovirus Treatment in KRAS Mutated Colorectal Cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Management and Research","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Oncolytics Biotech; Yeshiva University","keywords":"KRAS; Colorectal cancer; Peripheral blood mononuclear cell; Transcriptome; Cancer research; Immune system; Gene; Oncolytic virus; Biology; Cancer; Medicine; Immunology; Gene expression; Internal medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000820089,0.0001459081,0.0003549425,0.0003178886,0.0001892206,0.000253843,0.00006215526,0.0001934733,0.001538358],"category_scores_gemma":[0.0001301891,0.00008623132,0.0002563606,0.0003170487,0.0001300857,0.0001332706,0.0001661457,0.0003621624,0.0003018098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001817128,"about_ca_system_score_gemma":0.0001501432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003778194,"about_ca_topic_score_gemma":0.0005580407,"domain_scores_codex":[0.99988,0.00001493187,0.000006035862,0.00003409617,0.00003003512,0.00003487832],"domain_scores_gemma":[0.9999295,0.00001005423,0.00001937341,0.000005287488,0.00001635147,0.00001933107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008567573,0.00004383903,0.006792014,0.0001228377,0.00002251786,0.00008826194,0.0001102686,0.0001313164,0.9872321,0.00004407156,0.0002101987,0.004345936],"study_design_scores_gemma":[0.00006145326,0.002111977,0.6467946,0.0000519279,0.0001681466,0.0008880123,0.001034577,0.003545717,0.335811,0.0002588104,0.009238117,0.0000356553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935441,0.001805624,0.0009593061,0.00006729132,0.00003538295,0.0000325643,0.00228887,0.00004687269,0.001219984],"genre_scores_gemma":[0.9926179,0.0009288152,0.001043232,0.0001072009,0.0000152793,0.0001184232,0.002814985,0.00001832014,0.002335778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001538358,"threshold_uncertainty_score":0.005146325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04452024175985621,"score_gpt":0.3903088371135194,"score_spread":0.3457885953536632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}