{"id":"W3195854721","doi":"10.3390/vaccines9080917","title":"The Promise and Challenges of Cyclic Dinucleotides as Molecular Adjuvants for Vaccine Development","year":2021,"lang":"en","type":"review","venue":"Vaccines","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Brock University","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; National Research Council","keywords":"Crosstalk; Innate immune system; Immune system; Stimulator of interferon genes; Signal transduction; Acquired immune system; Biology; Vaccine adjuvant; Computational biology; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005102251,0.0005622794,0.0007854922,0.00119037,0.0001931498,0.0007852169,0.0005638258,0.001073776,0.002253636],"category_scores_gemma":[0.0004531496,0.00022748,0.0003019094,0.000988969,0.0004112677,0.001438672,0.000556634,0.001781584,0.001366061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004376386,"about_ca_system_score_gemma":0.0006907834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004271207,"about_ca_topic_score_gemma":0.0007621304,"domain_scores_codex":[0.9998652,0.00002861044,0.00001345533,0.00002091694,0.0000535158,0.00001827211],"domain_scores_gemma":[0.9998067,0.00009503272,0.00002483864,0.0000067535,0.00004350139,0.00002328895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008154993,0.00009405603,0.000138064,0.01239468,0.00004773507,0.0002157465,0.00007367393,0.0007255106,0.01411117,0.01559115,0.01813606,0.9383906],"study_design_scores_gemma":[0.000009231813,0.0001246812,0.0003270125,0.001490505,0.00003276288,0.0005672402,0.00004561373,0.0001618983,0.001849441,0.003872029,0.9915052,0.00001432556],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002518769,0.9978855,0.0002645552,0.0003643745,0.0002325709,0.000003374821,0.000009510739,0.000006162112,0.0009820361],"genre_scores_gemma":[0.001106277,0.9974927,0.0003575902,0.0001979614,0.0001993801,0.00000681364,0.00001701428,0.00000165026,0.0006206988],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002253636,"threshold_uncertainty_score":0.007539093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04687741968362245,"score_gpt":0.3186811369236125,"score_spread":0.27180371723999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}