{"id":"W3195854721","doi":"10.3390/vaccines9080917","title":"The Promise and Challenges of Cyclic Dinucleotides as Molecular Adjuvants for Vaccine Development","year":2021,"lang":"en","type":"review","venue":"Vaccines","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Brock University","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; National Research Council","keywords":"Crosstalk; Innate immune system; Immune system; Stimulator of interferon genes; Signal transduction; Acquired immune system; Biology; Vaccine adjuvant; Computational biology; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003257552,0.000375746,0.001360424,0.0001208762,0.0001918652,0.00002031944,0.0003283542,0.0003062495,0.00007028736],"category_scores_gemma":[0.0004140809,0.000222514,0.0002792569,0.00008000502,0.00003840917,0.00002954468,0.0002162434,0.0001876086,0.00004559267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002180927,"about_ca_system_score_gemma":0.0002459312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004606532,"about_ca_topic_score_gemma":0.00001369165,"domain_scores_codex":[0.9983248,0.0002980813,0.0006647834,0.0003648797,0.00002834259,0.0003191786],"domain_scores_gemma":[0.998423,0.0007084702,0.000336482,0.0003811073,0.0001322541,0.00001870541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001419117,0.00005402379,0.00000110542,0.00469432,0.0009241635,0.000003757036,0.0001202878,1.223018e-8,0.0007305874,0.001245639,0.0007277687,0.9913564],"study_design_scores_gemma":[0.0005807754,0.0001733585,0.00003823349,0.004923224,0.0003243182,0.0001582172,0.0001470081,4.116619e-8,0.009243474,0.0000278226,0.9841489,0.0002345988],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001236686,0.997025,0.000003404375,0.0002349703,0.0004747687,0.0008622522,0.00001674989,0.00002432305,0.0001218599],"genre_scores_gemma":[0.0002552926,0.9965373,0.00006589292,0.00001608092,0.00002411555,0.0002628886,0.00007009808,0.00004668071,0.002721711],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9911218,"threshold_uncertainty_score":0.9073858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04687741968362245,"score_gpt":0.3186811369236125,"score_spread":0.27180371723999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}