{"id":"W3195883935","doi":"10.1002/mds.28750","title":"Striatal Cholinergic Dysregulation after Neonatal Decrease in X‐Linked Dystonia Parkinsonism‐Related <scp>TAF1</scp> Isoforms","year":2021,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Dystonia Medical Research Foundation Canada","keywords":"Parkinsonism; Gene knockdown; Dystonia; Biology; TAF1; Neuroscience; Alternative splicing; Striatum; Cholinergic; Internal medicine; Gene isoform; Medicine; Dopamine; Genetics; Gene; Gene expression; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001519326,0.0003671581,0.0003793299,0.0002928517,0.000163274,0.0002596222,0.0002854689,0.0003958356,0.001516875],"category_scores_gemma":[0.0001807308,0.0001187309,0.0002355952,0.00009602382,0.0003553207,0.0002514225,0.000231054,0.0008322515,0.0002993371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004881974,"about_ca_system_score_gemma":0.0003365542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001539731,"about_ca_topic_score_gemma":0.002318113,"domain_scores_codex":[0.9998493,0.00001445657,0.00001760028,0.00004727594,0.00004262436,0.00002862349],"domain_scores_gemma":[0.999756,0.00002663798,0.00008749765,0.00001494711,0.00003325879,0.00008165281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003464971,0.00005675952,0.001081834,0.00006349513,0.00001708836,0.0003729633,0.00004861683,0.00003499862,0.9957981,0.0000620574,0.00006960155,0.002048049],"study_design_scores_gemma":[0.00003198582,0.001046442,0.06624085,0.00003736508,0.00009415195,0.001720371,0.0002165066,0.0005040357,0.9278452,0.00007480429,0.002175765,0.00001248611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958709,0.001573761,0.0009081539,0.00007118761,0.00002857711,0.00001759377,0.0005524019,0.00006326518,0.0009141648],"genre_scores_gemma":[0.9937024,0.001114882,0.0008948862,0.00009081276,0.000008887747,0.00007757434,0.0008355281,0.00003784,0.003237223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001539731,"threshold_uncertainty_score":0.005074441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007344450605791482,"score_gpt":0.2320355930202176,"score_spread":0.2246911424144261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}