{"id":"W3195895030","doi":"10.3390/cells10082089","title":"Immobilization of Jagged1 Enhances Vascular Smooth Muscle Cells Maturation by Activating the Notch Pathway","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Cell biology; Notch signaling pathway; HES1; Progenitor cell; Calponin; Myosin; Biology; Vascular smooth muscle; Cell fate determination; Notch proteins; Stem cell; Transcription factor; Actin; Signal transduction; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002009334,0.0000913137,0.00009569152,0.00001525438,0.00008487904,0.00003458433,0.0001256919,0.00009376368,0.00008374744],"category_scores_gemma":[0.0000745876,0.00007362806,0.00008258832,0.0001619486,0.00005486003,0.000006777523,0.0001017499,0.00008755445,0.00001577235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001139618,"about_ca_system_score_gemma":0.0001021752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000184555,"about_ca_topic_score_gemma":0.00002525085,"domain_scores_codex":[0.9990822,0.0001379552,0.0001624414,0.0002480591,0.0001996868,0.0001696446],"domain_scores_gemma":[0.999316,0.00004885633,0.00006122867,0.0003486905,0.0001892106,0.00003595189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009437868,0.0000453918,0.000009713909,0.00004101742,0.0000161447,9.075642e-7,0.00008075911,0.00003849451,0.9861755,0.000004511621,0.0007923826,0.01278578],"study_design_scores_gemma":[0.0001290001,0.00005775609,0.0002666543,0.00001179395,0.000005116778,4.231912e-7,0.0001696667,0.0001492197,0.9547803,0.00001115772,0.04433806,0.00008079993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953523,0.001633087,0.001505107,0.00005042867,0.0001329073,0.0001945789,0.0000200708,0.000006055534,0.001105445],"genre_scores_gemma":[0.9981816,0.0003161648,0.0001861659,0.00005274071,0.00008500123,0.00001461124,0.0001200369,0.00001599539,0.001027621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04354568,"threshold_uncertainty_score":0.3002465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007296843234701051,"score_gpt":0.2398525773240585,"score_spread":0.2325557340893575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}