{"id":"W3195895030","doi":"10.3390/cells10082089","title":"Immobilization of Jagged1 Enhances Vascular Smooth Muscle Cells Maturation by Activating the Notch Pathway","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Cell biology; Notch signaling pathway; HES1; Progenitor cell; Calponin; Myosin; Biology; Vascular smooth muscle; Cell fate determination; Notch proteins; Stem cell; Transcription factor; Actin; Signal transduction; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001093816,0.0002663831,0.0001601571,0.0001459598,0.0001263632,0.0002671561,0.0001416935,0.0002696228,0.001137746],"category_scores_gemma":[0.00008405268,0.0001132897,0.0002166015,0.00007883547,0.000134351,0.0001404207,0.0002299884,0.0003304658,0.0003171198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002527247,"about_ca_system_score_gemma":0.0001155732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003954587,"about_ca_topic_score_gemma":0.0008454177,"domain_scores_codex":[0.9998939,0.00001677101,0.00001042715,0.00002350638,0.00001793473,0.00003753],"domain_scores_gemma":[0.9999437,0.000009815417,0.00001531696,0.000005617352,0.000006830227,0.00001875018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003559583,0.00001410488,0.00005564937,0.00002127057,0.000001916735,0.00001116425,0.000006758997,0.00002847208,0.9994627,0.00001663599,0.00001246287,0.000333397],"study_design_scores_gemma":[0.000004732955,0.0001085072,0.001093893,0.000002446206,0.000006066376,0.00003066464,0.00001077757,0.0003035337,0.9977811,0.000006258204,0.0006502382,0.000001754383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971427,0.0009149845,0.001155424,0.0000611796,0.00001713067,0.00001105941,0.00005365173,0.00003282064,0.0006109369],"genre_scores_gemma":[0.996363,0.0005610202,0.001344515,0.00004715389,0.000007235036,0.00001444442,0.0001125267,0.000006883418,0.001543275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137746,"threshold_uncertainty_score":0.003806114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007296843234701051,"score_gpt":0.2398525773240585,"score_spread":0.2325557340893575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}