{"id":"W3195922641","doi":"10.3389/fncel.2021.702685","title":"Astrocytes in Down Syndrome Across the Lifespan","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cellular Neuroscience","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal General Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Azrieli Foundation; Canada First Research Excellence Fund; Faculty of Medicine, McGill University; International Development Research Centre; McGill University","keywords":"Neuroscience; Synaptogenesis; Biology; Neurodegeneration; Phenotype; Central nervous system; Disease; Medicine; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004711185,0.0009131108,0.00109653,0.002327727,0.0002524487,0.0008747423,0.0006391192,0.001204601,0.002140854],"category_scores_gemma":[0.0006654194,0.0001986186,0.0003321873,0.001375658,0.0004435217,0.0009455898,0.000781158,0.001425695,0.001292734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006739136,"about_ca_system_score_gemma":0.0008662072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001595712,"about_ca_topic_score_gemma":0.002367376,"domain_scores_codex":[0.9998562,0.00002554477,0.00003102927,0.00002440141,0.00004792039,0.00001491003],"domain_scores_gemma":[0.9998003,0.00009067775,0.00002871231,0.000005020471,0.00005140138,0.00002397944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001059218,0.0000340149,0.0003356308,0.01181397,0.00008131195,0.0007921092,0.0001043332,0.0002619633,0.001583577,0.005057436,0.0315228,0.948307],"study_design_scores_gemma":[0.00001993583,0.00007613125,0.001331827,0.004402871,0.0001344657,0.005525986,0.00008899202,0.00007931179,0.0005328376,0.002573956,0.9852147,0.00001908239],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001141264,0.9985435,0.00008332979,0.0003530122,0.0002093039,0.000002978491,0.00001412777,0.000007030894,0.0006725986],"genre_scores_gemma":[0.0007441211,0.9981835,0.0001316626,0.0001917438,0.0002272946,0.000004629867,0.00002817461,0.000001220698,0.0004875263],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002327727,"threshold_uncertainty_score":0.007161856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07654333046620596,"score_gpt":0.3754945434945323,"score_spread":0.2989512130283263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}