{"id":"W3195958085","doi":"10.1136/bmjopen-2020-044885","title":"Phase 3 randomised trial of eltrombopag versus standard first-line pharmacological management for newly diagnosed immune thrombocytopaenia (ITP) in children: study protocol","year":2021,"lang":"en","type":"article","venue":"BMJ Open","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; Children's Hospital of Eastern Ontario","funders":"Novartis","keywords":"Medicine; Eltrombopag; Immune thrombocytopenia; Protocol (science); First line; Randomized controlled trial; Pediatrics; First line treatment; Physical therapy; Intensive care medicine; Internal medicine; Alternative medicine; Pathology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007459404,0.004030638,0.005937767,0.0006418001,0.0009827741,0.002418151,0.002681938,0.003480133,0.03664295],"category_scores_gemma":[0.007949937,0.001437117,0.003543583,0.0009288905,0.002030301,0.001576583,0.001055922,0.004699325,0.004840822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00259489,"about_ca_system_score_gemma":0.006696894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00238787,"about_ca_topic_score_gemma":0.004982102,"domain_scores_codex":[0.9963511,0.002164913,0.0002497913,0.0003561877,0.000303214,0.000574695],"domain_scores_gemma":[0.9967164,0.0008997697,0.00101388,0.0003095621,0.0002912619,0.0007690528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9842741,0.004320655,0.0003659769,0.001958154,0.000881696,0.00005831763,0.00005246988,0.0005011511,0.0008341137,0.0002229006,0.001791119,0.004739409],"study_design_scores_gemma":[0.9827304,0.01480746,0.0005792496,0.00009174582,0.0002337429,0.00001959752,0.00001335329,0.0001926049,0.0001049418,0.0001320327,0.001082871,0.00001197208],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2424241,0.004263732,0.003343252,0.002229693,0.002017445,0.7239165,0.01426498,0.0004667392,0.007073502],"genre_scores_gemma":[0.189524,0.002731816,0.006480594,0.00270111,0.0007024139,0.7854449,0.003932282,0.00007482254,0.008408078],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03664295,"threshold_uncertainty_score":0.1225829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08660717936402325,"score_gpt":0.4656429047199479,"score_spread":0.3790357253559247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}