{"id":"W3195965191","doi":"10.3390/pharmaceutics13081261","title":"Nanoparticulate Drug Delivery Strategies to Address Intestinal Cytochrome P450 CYP3A4 Metabolism towards Personalized Medicine","year":2021,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Northwestern Polytechnical University; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Northwestern University","keywords":"CYP3A4; Drug; Pharmacology; Bioavailability; Drug metabolism; Pharmacokinetics; Cytochrome P450; Drug delivery; Chemistry; Medicine; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002374371,0.000633225,0.0006570538,0.001412582,0.0001656319,0.0005429664,0.000404478,0.0006565002,0.002970127],"category_scores_gemma":[0.0002612205,0.0002037057,0.0005312625,0.0008606362,0.0001868985,0.0006808161,0.0004363646,0.001021986,0.001316806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000372193,"about_ca_system_score_gemma":0.000439849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004958062,"about_ca_topic_score_gemma":0.0008834797,"domain_scores_codex":[0.9998922,0.00001830222,0.000008935249,0.00002251961,0.00004359353,0.00001435157],"domain_scores_gemma":[0.9999371,0.00002465601,0.00001265345,0.000002890346,0.00001737229,0.000005320335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007401227,0.0001747394,0.0002005841,0.01913247,0.0001242724,0.0003808872,0.00008361565,0.001096843,0.03426034,0.008143412,0.01809287,0.918236],"study_design_scores_gemma":[0.00002154199,0.0002244564,0.0007486258,0.001444965,0.0001517905,0.001384322,0.00004280631,0.0005733274,0.01014563,0.001847019,0.9833927,0.00002279001],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001999484,0.989701,0.002229878,0.0004043538,0.0002594645,0.00003337711,0.0000717583,0.00005131651,0.005249348],"genre_scores_gemma":[0.009698352,0.9836726,0.002026905,0.0003436025,0.000118517,0.00004456923,0.0001027396,0.000009000033,0.003983801],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002970127,"threshold_uncertainty_score":0.009936094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2717321492503962,"score_gpt":0.5166222329162328,"score_spread":0.2448900836658366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}