{"id":"W3196009884","doi":"10.1038/s41467-021-24982-0","title":"Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; University Health Network; University of Calgary; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Office of Extramural Research, National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Hospital for Sick Children; Ontario Innovation Trust; Scheme for Promotion of Academic and Research Collaboration","keywords":"Phagosome; Listeria monocytogenes; Intracellular parasite; Microbiology; Biology; Interferon; Immune system; Listeria; Cell biology; Intracellular; Virulence; Signal transduction; Transmembrane protein; Immunology; Bacteria; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001523106,0.0002832877,0.0002297228,0.0001111197,0.0001498427,0.0002074864,0.0001992171,0.0003495709,0.001056058],"category_scores_gemma":[0.0000973291,0.00008341311,0.0002939759,0.00007673223,0.0002560863,0.0001157836,0.0001620444,0.0006692108,0.000336514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002835726,"about_ca_system_score_gemma":0.0002329141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002826907,"about_ca_topic_score_gemma":0.0002893892,"domain_scores_codex":[0.9998872,0.00001943556,0.00001191253,0.00001991632,0.00002287622,0.00003862768],"domain_scores_gemma":[0.999892,0.00001542898,0.00004276127,0.00001402364,0.000008733799,0.000027046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001640509,0.00001810432,0.0001047553,0.00001898281,0.000002934805,0.0000518314,0.000003984371,0.00004103522,0.9988269,0.00008162019,0.00005222058,0.0006334459],"study_design_scores_gemma":[0.000055267,0.0004038945,0.002212641,0.000007602716,0.00001010949,0.0004973062,0.00001744448,0.0008465298,0.9935868,0.0001015048,0.002256554,0.000004283202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926786,0.001406085,0.003079299,0.0004102255,0.000082955,0.00003072551,0.0005511739,0.0002036236,0.001557354],"genre_scores_gemma":[0.9964145,0.0002305835,0.001687488,0.0001541288,0.00001153129,0.00002672045,0.0003970509,0.00002834632,0.001049692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056058,"threshold_uncertainty_score":0.003532827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0232761553390591,"score_gpt":0.3072755247735839,"score_spread":0.2839993694345249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}