{"id":"W3196144717","doi":"10.1016/j.bbalip.2021.159032","title":"Biological action of docosahexaenoic acid in a 3D tissue-engineered psoriatic skin model: Focus on the PPAR signaling pathway","year":2021,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","topic":"Fatty Acid Research and Health","field":"Nursing","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut Universitaire de Cardiologie et de Pneumologie de Québec; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Docosahexaenoic acid; Psoriasis; Filaggrin; Eicosapentaenoic acid; Polyunsaturated fatty acid; Endocannabinoid system; Epidermis (zoology); Keratinocyte; Inflammation; Receptor; Biochemistry; Chemistry; Pharmacology; Cell biology; Biology; Endocrinology; Fatty acid; Immunology; In vitro; Atopic dermatitis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559443,0.0003025972,0.000288809,0.0002077987,0.0001618315,0.0003673706,0.0001306115,0.0004132718,0.001018221],"category_scores_gemma":[0.00005502449,0.000115095,0.0003644594,0.0001654925,0.0001987538,0.0001913247,0.0001296538,0.0006886806,0.000242316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194217,"about_ca_system_score_gemma":0.0002760408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008667739,"about_ca_topic_score_gemma":0.001348753,"domain_scores_codex":[0.9998925,0.00001456842,0.000006807662,0.00002036304,0.00004051211,0.00002532221],"domain_scores_gemma":[0.9999466,0.000008300324,0.000009655699,0.000007475177,0.000008056759,0.00001992081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001443687,0.00004980555,0.00004769719,0.00004109234,0.000004318854,0.00008180265,0.00001312904,0.0001279863,0.998316,0.00006541273,0.00004460476,0.00106378],"study_design_scores_gemma":[0.00003498996,0.0004552804,0.001313721,0.000009828824,0.00003476674,0.000258188,0.00007248478,0.001256549,0.9944215,0.00006537217,0.002068494,0.000008777642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855245,0.002872054,0.006667609,0.0002985708,0.0002770897,0.00005688209,0.0006359119,0.0001142871,0.003553112],"genre_scores_gemma":[0.9900466,0.001535523,0.004917776,0.0001357075,0.00001382309,0.00005103578,0.0002304615,0.00001445768,0.003054641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018221,"threshold_uncertainty_score":0.003406286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02563567112654982,"score_gpt":0.2848884688371046,"score_spread":0.2592527977105548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}