{"id":"W3196170706","doi":"10.1038/s41374-021-00654-x","title":"In vitro functional genetic modification of canine adenovirus type 2 genome by CRISPR/Cas9","year":2021,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"College of Veterinary Medicine, Auburn University; Centre National de la Recherche Scientifique; Institute of Genetics; Auburn University","keywords":"CRISPR; Cas9; Genome editing; Oncolytic virus; Biology; Genetic enhancement; Genome; Transgene; Viral vector; Computational biology; Genome engineering; Vectors in gene therapy; Gene; Viral replication; Adenoviridae; Virology; Genetics; Virus; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005481808,0.00042412,0.0002942011,0.0002699798,0.000296916,0.0004340976,0.0004161207,0.0004224092,0.001822281],"category_scores_gemma":[0.0002605293,0.0003034423,0.0004118569,0.000140366,0.0003262597,0.0002694067,0.0003123224,0.0007483838,0.0007238369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005800212,"about_ca_system_score_gemma":0.0004102812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002046639,"about_ca_topic_score_gemma":0.002861452,"domain_scores_codex":[0.9995983,0.00006980383,0.00005798089,0.00009309303,0.0001046576,0.0000760843],"domain_scores_gemma":[0.9998178,0.00004344043,0.00004219592,0.00003994782,0.0000231679,0.00003358955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003652463,0.00001248825,0.00006757308,0.00003452253,0.000003695776,0.0000413466,0.00002696725,0.00008192539,0.9986523,0.0003957728,0.00006089154,0.0005859871],"study_design_scores_gemma":[0.000007369681,0.000071962,0.0004485101,0.000003554899,0.00001048136,0.0001536036,0.00002090424,0.0009984224,0.9937807,0.00005016901,0.004448282,0.000006138204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9078944,0.001576474,0.0778069,0.0002811036,0.0003706914,0.0003017242,0.002142613,0.0008480194,0.008777917],"genre_scores_gemma":[0.9603267,0.0005009045,0.02785219,0.00005916665,0.00001486145,0.0001093961,0.001876179,0.0001091955,0.009151369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046639,"threshold_uncertainty_score":0.006096184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02236333456449269,"score_gpt":0.2777987461645176,"score_spread":0.2554354116000249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}