{"id":"W3196170706","doi":"10.1038/s41374-021-00654-x","title":"In vitro functional genetic modification of canine adenovirus type 2 genome by CRISPR/Cas9","year":2021,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"College of Veterinary Medicine, Auburn University; Centre National de la Recherche Scientifique; Institute of Genetics; Auburn University","keywords":"CRISPR; Cas9; Genome editing; Oncolytic virus; Biology; Genetic enhancement; Genome; Transgene; Viral vector; Computational biology; Genome engineering; Vectors in gene therapy; Gene; Viral replication; Adenoviridae; Virology; Genetics; Virus; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001764097,0.0001073433,0.0001110872,0.00006443652,0.00003786396,0.00001321943,0.00009906948,0.0001301576,0.00009764458],"category_scores_gemma":[0.0001100719,0.0001256023,0.0000226811,0.0005030424,0.00009764215,0.000009896919,0.00003254943,0.00009861711,0.00002028521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004864583,"about_ca_system_score_gemma":0.000599143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002809711,"about_ca_topic_score_gemma":0.00009584816,"domain_scores_codex":[0.998909,0.0001778396,0.0002426849,0.0002990684,0.0002100524,0.0001613434],"domain_scores_gemma":[0.9990581,0.000009541915,0.00008855104,0.0003147123,0.0004474997,0.00008160259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003432228,0.00004361387,0.001072314,0.00001914012,0.0000202809,0.000002946222,0.00004023378,0.000831308,0.9960319,0.00002504745,0.001429986,0.0001399467],"study_design_scores_gemma":[0.000418242,0.0002394314,0.005736241,0.000003998728,0.000006790072,0.000002168053,0.00003275694,0.0001719484,0.9895167,0.00009316899,0.003661502,0.0001170108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960382,0.002966156,0.0002719164,0.0003284303,0.0001026246,0.0001229859,0.0001199798,0.000007194473,0.00004248478],"genre_scores_gemma":[0.9971115,0.0001835147,0.0004612418,0.0007142372,0.0001377586,0.00002748649,0.00111214,0.0000230696,0.0002290749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006515217,"threshold_uncertainty_score":0.5121912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02236333456449269,"score_gpt":0.2777987461645176,"score_spread":0.2554354116000249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}