{"id":"W3196177535","doi":"10.1016/j.nicl.2021.102804","title":"Longitudinal brain atrophy and CSF biomarkers in early-onset Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; European Regional Development Fund; Instituto de Salud Carlos III; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; Centres de Recerca de Catalunya; H. Lundbeck A/S; Servier; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Eisai; European Commission; Ministerio de Ciencia e Innovación; Janssen Research and Development; Generalitat de Catalunya; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Johnson and Johnson; Meso Scale Diagnostics; Departament de Salut, Generalitat de Catalunya; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Merck; Fujirebio Europe; Alzheimer's Association","keywords":"Atrophy; Early-onset Alzheimer's disease; Posterior cortical atrophy; Alzheimer's Disease Neuroimaging Initiative; Cardiology; Internal medicine; Cohort; Hippocampus; Medicine; Psychology; Alzheimer's disease; Pathology; Neuroscience; Dementia; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0005647064,0.0002251525,0.0003521654,0.0001015724,0.0001769631,0.0001158104,0.0001884227,0.00007657332,0.00006084658],"category_scores_gemma":[0.05693764,0.0002315575,0.0001832702,0.0004861262,0.0007006269,0.0002776465,0.0004718203,0.0004915778,0.0001097532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001754551,"about_ca_system_score_gemma":0.0001425879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001577349,"about_ca_topic_score_gemma":0.00004155527,"domain_scores_codex":[0.9963985,0.0009622468,0.0005110946,0.001391288,0.0003532064,0.0003836798],"domain_scores_gemma":[0.9820402,0.01698985,0.0000937246,0.000523122,0.00006231557,0.0002908137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005339672,0.0004541426,0.9711858,0.00001606202,0.00003813966,0.00469274,0.00003568027,0.000004929938,0.003094053,0.0002319946,0.01648287,0.003229596],"study_design_scores_gemma":[0.001060722,0.0001831574,0.9913114,0.00001948107,0.00004202137,0.00007883405,0.00001130996,0.0002974324,0.0007140206,0.0008727947,0.005182956,0.0002259161],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621632,0.0003887846,0.00002712786,0.03570289,0.0008148243,0.0001983175,0.00006136238,0.00008263102,0.0005609321],"genre_scores_gemma":[0.9848943,0.0001546244,0.0001481263,0.01443014,0.0001747035,0.00001959021,0.000003450727,0.00003025736,0.0001448501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05637293,"threshold_uncertainty_score":0.9510062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1335327344956899,"score_gpt":0.3729159126035885,"score_spread":0.2393831781078986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}