{"id":"W3196177535","doi":"10.1016/j.nicl.2021.102804","title":"Longitudinal brain atrophy and CSF biomarkers in early-onset Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; European Regional Development Fund; Instituto de Salud Carlos III; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; Centres de Recerca de Catalunya; H. Lundbeck A/S; Servier; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Eisai; European Commission; Ministerio de Ciencia e Innovación; Janssen Research and Development; Generalitat de Catalunya; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Johnson and Johnson; Meso Scale Diagnostics; Departament de Salut, Generalitat de Catalunya; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Merck; Fujirebio Europe; Alzheimer's Association","keywords":"Atrophy; Early-onset Alzheimer's disease; Posterior cortical atrophy; Alzheimer's Disease Neuroimaging Initiative; Cardiology; Internal medicine; Cohort; Hippocampus; Medicine; Psychology; Alzheimer's disease; Pathology; Neuroscience; Dementia; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007342758,0.000502608,0.0004392174,0.001195387,0.0004015093,0.000576548,0.0002472645,0.0004582856,0.0007024813],"category_scores_gemma":[0.001407416,0.0002293112,0.0002979996,0.0005666037,0.0002572656,0.0005138451,0.0004747029,0.0003623478,0.0001829403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002882319,"about_ca_system_score_gemma":0.0001855864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003867796,"about_ca_topic_score_gemma":0.004893194,"domain_scores_codex":[0.9998192,0.0000368081,0.00002483994,0.00005640224,0.00002904183,0.00003371544],"domain_scores_gemma":[0.9991938,0.0001006865,0.0003481759,0.00006404764,0.0001528414,0.000140464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006389124,0.0000772343,0.9945809,0.00001791927,0.00007122095,0.0002111127,0.0001448284,0.00005594559,0.001567328,0.00001281026,0.00005966696,0.002562063],"study_design_scores_gemma":[0.000006388371,0.0001009165,0.9992648,0.000005654884,0.00001839938,0.0002486258,0.00006361715,0.00005432425,0.0001320333,0.00004000817,0.00006287515,0.000002438125],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993113,0.000406555,0.00004265777,0.00001030775,0.000002539011,0.000002709214,0.00008563496,0.000002815896,0.000135476],"genre_scores_gemma":[0.9993595,0.0001488479,0.0001207408,0.00001409701,0.000005538772,0.000004748704,0.0002044072,0.000001970145,0.0001402395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003867796,"threshold_uncertainty_score":0.007690609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1335327344956899,"score_gpt":0.3729159126035885,"score_spread":0.2393831781078986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}