{"id":"W3196190359","doi":"10.1371/journal.ppat.1009800","title":"SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Novo Nordisk Fonden; Israel Science Foundation; University of California, San Francisco; University of Melbourne; Monash University; McGill University; National Health and Medical Research Council; State Government of Victoria; Johns Hopkins University","keywords":"Interferon γ; Interferon; Production (economics); Coronavirus disease 2019 (COVID-19); Virology; Interferon gamma; Chemistry; Biology; Medicine; Immunology; Cytokine; Internal medicine; Economics; Microeconomics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893825,0.000275748,0.0004495868,0.00008191453,0.0001753186,0.00002720756,0.0002519569,0.000256537,0.0001686397],"category_scores_gemma":[0.001831788,0.0001733964,0.0001062789,0.0001314245,0.0004127847,0.0001119238,0.000225595,0.0003367378,0.00007618012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002277333,"about_ca_system_score_gemma":0.0000742254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004039185,"about_ca_topic_score_gemma":0.00006151107,"domain_scores_codex":[0.997857,0.0008225776,0.0003872504,0.0004617629,0.00008887118,0.0003825267],"domain_scores_gemma":[0.9982633,0.0007871503,0.0001620019,0.0005336982,0.0002356274,0.00001822862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008427931,0.0003375399,0.0002295995,0.0002322439,0.000414461,0.00001888477,0.001245618,8.10563e-8,0.9885771,0.0000228005,0.007607962,0.0004709707],"study_design_scores_gemma":[0.0008388194,0.0004284571,0.0005900455,0.0001689338,0.0001882162,0.00009255273,0.0006354246,0.000002499629,0.9904983,0.00001271776,0.006331928,0.0002120802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903741,0.006363336,0.000009528356,0.0008637757,0.001351745,0.0003986752,0.0004155082,0.00007567165,0.0001476704],"genre_scores_gemma":[0.9956133,0.0008942675,0.00001703918,0.000256629,0.00004514261,0.00006479312,0.0002260881,0.00003359832,0.002849145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005469068,"threshold_uncertainty_score":0.7070898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115858947641298,"score_gpt":0.2291548102666051,"score_spread":0.2175689155024753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}