{"id":"W3196190359","doi":"10.1371/journal.ppat.1009800","title":"SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Novo Nordisk Fonden; Israel Science Foundation; University of California, San Francisco; University of Melbourne; Monash University; McGill University; National Health and Medical Research Council; State Government of Victoria; Johns Hopkins University","keywords":"Interferon γ; Interferon; Production (economics); Coronavirus disease 2019 (COVID-19); Virology; Interferon gamma; Chemistry; Biology; Medicine; Immunology; Cytokine; Internal medicine; Economics; Microeconomics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946687,0.0004667796,0.0003292704,0.0001795338,0.0001026024,0.0002735675,0.0001448143,0.0002260396,0.001281268],"category_scores_gemma":[0.0001174458,0.0001352565,0.0004252641,0.00009261469,0.0002568445,0.000155015,0.0001537709,0.0006639624,0.0005201773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001612108,"about_ca_system_score_gemma":0.0002225271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002401288,"about_ca_topic_score_gemma":0.0003623325,"domain_scores_codex":[0.9997644,0.00004098612,0.0000272126,0.00004162109,0.00007326201,0.00005251743],"domain_scores_gemma":[0.9998426,0.00002797134,0.00004752674,0.00002496049,0.00002306871,0.00003367577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005390266,0.0000207594,0.00005943651,0.00001589362,0.000001667813,0.000009174938,0.000004095889,0.0000186644,0.9995685,0.00001290293,0.000008653657,0.0002263959],"study_design_scores_gemma":[0.000007912686,0.0003344235,0.00166021,0.00000422841,0.000006250389,0.0001002014,0.00001466833,0.0003216571,0.9966215,0.00001048956,0.0009166577,0.000001772619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961359,0.000827326,0.001453226,0.00006487891,0.00003393275,0.0000304831,0.0004249869,0.00005340042,0.0009757933],"genre_scores_gemma":[0.9893475,0.0007702977,0.003440419,0.00009239195,0.00002081103,0.00005844418,0.002554571,0.00004087235,0.003674737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281268,"threshold_uncertainty_score":0.00428623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115858947641298,"score_gpt":0.2291548102666051,"score_spread":0.2175689155024753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}