{"id":"W3196212544","doi":"10.14309/ctg.0000000000000397","title":"Integrating Tumor Sequencing Into Clinical Practice for Patients With Mismatch Repair-Deficient Lynch Syndrome Spectrum Cancers","year":2021,"lang":"en","type":"article","venue":"Clinical and Translational Gastroenterology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Island Health; BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Lynch syndrome; Microsatellite instability; MSH6; MLH1; PMS2; Medicine; MSH2; Germline mutation; Germline; Genetic testing; Oncology; Cancer research; Genetics; DNA mismatch repair; Cancer; Colorectal cancer; Bioinformatics; Internal medicine; Biology; Mutation; Microsatellite; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002056418,0.0003153431,0.0002234381,0.001074515,0.0003475288,0.0005221554,0.0005034598,0.0005882989,0.001954316],"category_scores_gemma":[0.00659049,0.000136739,0.0001382492,0.0003822234,0.0003602336,0.0005342318,0.0005878754,0.0004269579,0.0007381119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002556537,"about_ca_system_score_gemma":0.0007907373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049419,"about_ca_topic_score_gemma":0.001619354,"domain_scores_codex":[0.9991301,0.0003921837,0.0001240001,0.0001178894,0.0001714381,0.00006451421],"domain_scores_gemma":[0.9960451,0.00177391,0.0008668552,0.0001755317,0.0005870797,0.0005515203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003375918,0.000129489,0.8393651,0.0002400033,0.00002960921,0.01184598,0.0007469957,0.0007646161,0.008951561,0.0002136371,0.005007357,0.1323681],"study_design_scores_gemma":[0.0001202847,0.001661662,0.8073437,0.001358275,0.0001255373,0.1365506,0.003661648,0.01138423,0.01584601,0.002152899,0.01971955,0.00007560503],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966835,0.006644407,0.01128137,0.005300016,0.0001750101,0.0002584935,0.0003003119,0.0004424937,0.008762934],"genre_scores_gemma":[0.9880279,0.001717374,0.008579607,0.0009619474,0.0002131518,0.00004926822,0.0001689505,0.00002853955,0.0002531728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002056418,"threshold_uncertainty_score":0.01087552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02913942004626488,"score_gpt":0.3415939593903307,"score_spread":0.3124545393440659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}