{"id":"W3196234584","doi":"10.1101/2021.08.25.457678","title":"Hematopoiesis at single cell resolution spanning human development and maturation","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Haematopoiesis; Progenitor cell; Biology; Cell biology; Stem cell; Immunology; Cell; Regeneration (biology); Cell fate determination; Progenitor; RNA; Gene; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002475898,0.0004212552,0.0003387711,0.00009311047,0.0003419504,0.0002168317,0.0002097479,0.0006138054,0.00001320265],"category_scores_gemma":[0.00004246982,0.0004944571,0.00009991921,0.0001134094,0.00008333875,0.00001106991,0.0005026854,0.0002807527,0.000005875557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001794816,"about_ca_system_score_gemma":0.0002401437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002622322,"about_ca_topic_score_gemma":0.00002538608,"domain_scores_codex":[0.9979698,0.00008741909,0.0004354499,0.0009122888,0.0002211056,0.0003739099],"domain_scores_gemma":[0.9986909,0.000008878163,0.000255294,0.0006337888,0.0002503226,0.0001608202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003789458,0.0001206111,0.002492409,0.0003528145,0.00006347862,0.00001516117,0.00003284651,0.00004588402,0.9966422,0.00001471925,0.0001799482,0.000002030435],"study_design_scores_gemma":[0.000430699,0.0000629626,0.01669282,0.0001992107,0.00005227701,6.192617e-8,0.000007843384,0.00006090314,0.9770165,2.701915e-7,0.004907445,0.0005689773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944944,0.002625962,0.00203269,0.00003773064,0.0004036593,0.0002792687,0.00001958505,0.00007559636,0.00003110221],"genre_scores_gemma":[0.9896486,0.0001328311,0.009605212,0.0001045834,0.0003095694,0.00005546094,0.00001168929,0.00009143011,0.00004065979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01962567,"threshold_uncertainty_score":0.9997507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01676842092133472,"score_gpt":0.2050231539570486,"score_spread":0.1882547330357139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}