{"id":"W3196238675","doi":"10.1016/j.mvr.2021.104232","title":"Hypoxia alters the expression of ACE2 and TMPRSS2 SARS-CoV-2 cell entry mediators in hCMEC/D3 brain endothelial cells","year":2021,"lang":"en","type":"article","venue":"Microvascular Research","topic":"Long-Term Effects of COVID-19","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Hypoxia (environmental); TMPRSS2; Endothelial stem cell; Angiotensin-converting enzyme 2; Cell biology; Coronavirus disease 2019 (COVID-19); Neuroscience; Biology; Chemistry; Medicine; Internal medicine; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009841366,0.0001621028,0.0002445264,0.0001369953,0.0002604766,0.000386584,0.0001161718,0.0002487276,0.002375733],"category_scores_gemma":[0.0001146287,0.0001046606,0.0002817003,0.0001725081,0.0001929238,0.0004141576,0.0001477991,0.0005006751,0.0003852637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000355284,"about_ca_system_score_gemma":0.0002506533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002537524,"about_ca_topic_score_gemma":0.002797985,"domain_scores_codex":[0.9998007,0.00001897264,0.00001531113,0.00003296492,0.0000355626,0.00009655482],"domain_scores_gemma":[0.9999202,0.000008592932,0.0000180974,0.000009448314,0.00001432259,0.00002933371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006848098,0.00007442847,0.0006517376,0.00002782674,0.00001050056,0.00008879472,0.00003685362,0.00004653303,0.9974022,0.000115878,0.0001612013,0.0006992594],"study_design_scores_gemma":[0.00005393081,0.000893328,0.06938925,0.000008600955,0.00004482159,0.0004130276,0.000471087,0.001462936,0.9221484,0.0001364107,0.004959979,0.00001813775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963915,0.0009657241,0.0005371051,0.0001598799,0.00005419672,0.000009145768,0.0008787648,0.00001827517,0.0009854675],"genre_scores_gemma":[0.9940653,0.0004736254,0.0003494925,0.000105782,0.00001987163,0.00003064181,0.001264462,0.000006841005,0.003683851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002537524,"threshold_uncertainty_score":0.007947564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02558212907434342,"score_gpt":0.3391403528822749,"score_spread":0.3135582238079315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}