{"id":"W3196275328","doi":"10.1016/j.jaad.2021.05.075","title":"Abrocitinib induction, randomized withdrawal, and retreatment in patients with moderate-to-severe atopic dermatitis: Results from the JAK1 Atopic Dermatitis Efficacy and Safety (JADE) REGIMEN phase 3 trial","year":2021,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Mitsubishi Tanabe Pharma Corporation; Castle Biosciences; Ortho Dermatologics; Amgen; Pfizer; Allergan; Meiji Seika Pharma; Inozyme Pharma; Eli Lilly and Company; Bristol-Myers Squibb; Incyte","keywords":"Medicine; Atopic dermatitis; Eczema Area and Severity Index; Regimen; Placebo; Adverse effect; Randomized controlled trial; Internal medicine; Maintenance therapy; Tolerability; Dermatology Life Quality Index; Dermatology; Chemotherapy; Psoriasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002450025,0.0007618212,0.001658413,0.0002156531,0.0003028201,0.0008693214,0.000539825,0.0007827511,0.003592766],"category_scores_gemma":[0.001665732,0.000292965,0.001780351,0.0003002973,0.000474809,0.0006455606,0.0002689614,0.001952396,0.0004937177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005474746,"about_ca_system_score_gemma":0.0007730647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004993606,"about_ca_topic_score_gemma":0.001932212,"domain_scores_codex":[0.9991972,0.0004718963,0.00006238723,0.00008992082,0.00008462802,0.00009398607],"domain_scores_gemma":[0.999101,0.000252899,0.0002372031,0.00008186393,0.00005789266,0.0002690874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9243522,0.005668483,0.003738556,0.0008112525,0.001732546,0.0000812143,0.0000828263,0.0003744118,0.004142085,0.000157899,0.002864244,0.05599425],"study_design_scores_gemma":[0.929956,0.05443595,0.01171685,0.00008132472,0.0008864578,0.0001502238,0.00002858984,0.0005300723,0.0004149733,0.0002227175,0.001559437,0.00001751863],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787447,0.01352119,0.0005073792,0.0008503764,0.0002812768,0.001616752,0.001222862,0.00008461778,0.003170689],"genre_scores_gemma":[0.9883323,0.004224243,0.0009298504,0.001358566,0.0003002404,0.001598685,0.001569087,0.00001871318,0.001668339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003592766,"threshold_uncertainty_score":0.0129571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104776535744163,"score_gpt":0.2823512698242048,"score_spread":0.2718736162497885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}