{"id":"W3196275328","doi":"10.1016/j.jaad.2021.05.075","title":"Abrocitinib induction, randomized withdrawal, and retreatment in patients with moderate-to-severe atopic dermatitis: Results from the JAK1 Atopic Dermatitis Efficacy and Safety (JADE) REGIMEN phase 3 trial","year":2021,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Mitsubishi Tanabe Pharma Corporation; Castle Biosciences; Ortho Dermatologics; Amgen; Pfizer; Allergan; Meiji Seika Pharma; Inozyme Pharma; Eli Lilly and Company; Bristol-Myers Squibb; Incyte","keywords":"Medicine; Atopic dermatitis; Eczema Area and Severity Index; Regimen; Placebo; Adverse effect; Randomized controlled trial; Internal medicine; Maintenance therapy; Tolerability; Dermatology Life Quality Index; Dermatology; Chemotherapy; Psoriasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137413,0.0002441815,0.001506914,0.000128513,0.0001561448,0.00002227498,0.0002000097,0.0001406747,0.00001445734],"category_scores_gemma":[0.0009141264,0.0001370692,0.0001427301,0.0003487345,0.0009342844,0.0001554928,0.0001073745,0.0005992894,0.000001406828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005370642,"about_ca_system_score_gemma":0.0002148976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004252967,"about_ca_topic_score_gemma":0.000009458057,"domain_scores_codex":[0.9967711,0.001127668,0.001226447,0.0002650468,0.0003504762,0.0002592449],"domain_scores_gemma":[0.9968686,0.001240268,0.00130766,0.0002452533,0.0001494532,0.0001888331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6167416,0.00169929,0.3462985,0.0001306455,0.002595492,0.0005864329,0.004836397,0.00005425982,0.00004975274,0.0002025542,0.02028308,0.006522026],"study_design_scores_gemma":[0.4621429,0.0002337646,0.5312053,0.0004092643,0.0005769092,0.002969812,0.0004133833,0.00003364437,0.0005606418,0.000462877,0.0008587452,0.000132812],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9426876,0.001370288,0.00004115289,0.05478961,0.0001100064,0.0008620097,0.00005385812,0.000008347048,0.00007710896],"genre_scores_gemma":[0.9930549,0.0008666427,0.0005390701,0.005391081,0.00007292334,0.00001640085,0.00001734569,0.0000165647,0.00002509905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1849068,"threshold_uncertainty_score":0.558952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104776535744163,"score_gpt":0.2823512698242048,"score_spread":0.2718736162497885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}