{"id":"W3196289286","doi":"10.1101/2021.08.30.21262305","title":"Genetic Factors Associated with Prostate Cancer Conversion from Active Surveillance to Treatment","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University of British Columbia; University Health Network","funders":"National Center for Advancing Translational Sciences; NorthShore University HealthSystem; University of Michigan; National Cancer Institute; College of Pharmacy, University of Michigan; National Institutes of Health; Vanderbilt University; U.S. Department of Defense","keywords":"Prostate cancer; Single-nucleotide polymorphism; Hazard ratio; Genome-wide association study; Medicine; Oncology; Confidence interval; Internal medicine; SNP; Decile; Cancer; Germline; Prostate-specific antigen; Genetics; Biology; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004478799,0.0002071285,0.0001970416,0.0004251184,0.0004258487,0.0007170636,0.0003118939,0.0004056836,0.001795065],"category_scores_gemma":[0.002273398,0.0001228051,0.0004869721,0.000849081,0.0003264569,0.0001618665,0.0002460674,0.0008057634,0.0001143726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000187329,"about_ca_system_score_gemma":0.0001898334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003257999,"about_ca_topic_score_gemma":0.003195413,"domain_scores_codex":[0.9995,0.0001911298,0.0000449455,0.0001280693,0.00008019833,0.00005569923],"domain_scores_gemma":[0.9982612,0.0004075187,0.0007685021,0.0001642495,0.0001134842,0.0002850838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000399739,0.00006324545,0.9938121,0.00001630612,0.0001993449,0.0002328885,0.00004985485,0.0001485221,0.002071504,0.00007663107,0.0002487727,0.002681022],"study_design_scores_gemma":[0.0000140645,0.00008662476,0.9983106,0.000006962709,0.00007150371,0.0005318475,0.00006075616,0.0003358093,0.0002229033,0.0001184774,0.0002348697,0.000005539944],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983914,0.0004752708,0.0002257057,0.0001340238,0.00001886737,0.000006282795,0.0003171731,0.00001212663,0.0004191036],"genre_scores_gemma":[0.9996082,0.00004578687,0.00008200264,0.0000311276,0.000008377505,0.000001855907,0.000125353,0.00000204108,0.00009532761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003257999,"threshold_uncertainty_score":0.006478071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04382431172953798,"score_gpt":0.3167049700574001,"score_spread":0.2728806583278621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}