{"id":"W3196290477","doi":"10.3389/fneur.2021.695696","title":"Plasma p-tau181 Level Predicts Neurodegeneration and Progression to Alzheimer's Dementia: A Longitudinal Study","year":2021,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, Davis; University of California, Los Angeles; Jewish General Hospital; University of South Florida; Dartmouth College; Brigham and Women's Hospital; Case Western Reserve University; Emory University; Cleveland Clinic; University of California, San Francisco; Georgetown University; Wake Forest University; Northwestern University; Ohio State University; Yale University; University of California, Irvine; USF Health Byrd Alzheimer's Institute; McGill University","keywords":"Dementia; Internal medicine; Alzheimer's Disease Neuroimaging Initiative; Medicine; Neuroimaging; Oncology; Psychology; Cerebrospinal fluid; Proportional hazards model; Cognition; Cardiology; Disease; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002676033,0.0001595439,0.0002932862,0.0002699119,0.00009035447,0.00003561958,0.00007352456,0.00008275276,0.00005362486],"category_scores_gemma":[0.0001449065,0.0001510393,0.00003296964,0.0003429663,0.00006782269,0.00008653211,0.0002032646,0.0003046028,0.000008396903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001162889,"about_ca_system_score_gemma":0.0001111157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001074467,"about_ca_topic_score_gemma":0.00008140189,"domain_scores_codex":[0.998074,0.0002999449,0.0002642308,0.0006084612,0.0003564776,0.0003968677],"domain_scores_gemma":[0.9993861,0.00003087905,0.00004114975,0.0002167738,0.0001311442,0.0001940011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008771507,0.0008444593,0.9667302,0.00001596235,0.000272308,0.001661589,0.0001902813,0.000009175154,0.0009905444,0.000009088149,0.005263163,0.02313604],"study_design_scores_gemma":[0.00347617,0.00386737,0.9871489,0.00001604626,0.0003014294,0.0001845663,0.0001432749,0.001217359,0.002316933,0.00003776303,0.00118581,0.0001043216],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915018,0.000940338,0.002299814,0.003069774,0.0006378309,0.001169061,0.000006295812,0.00003127544,0.0003437918],"genre_scores_gemma":[0.9953663,0.00006445959,0.003119975,0.001038796,0.00009943425,0.0001776735,0.00002693975,0.00002077047,0.00008567685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02303172,"threshold_uncertainty_score":0.6159206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05006669688072009,"score_gpt":0.3360571090405299,"score_spread":0.2859904121598099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}