{"id":"W3196305491","doi":"10.1093/molbev/msab263","title":"A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution","year":2021,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Biology; Substitution (logic); Amino acid substitution; Bitter taste; Taste; Function (biology); Taste receptor; Evolutionary biology; Genetics; Biochemistry; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522164,0.0002493074,0.0003029312,0.0003731386,0.0003175463,0.0003613908,0.0001520091,0.0002757488,0.002249115],"category_scores_gemma":[0.000317385,0.00009687529,0.0003002692,0.0003614155,0.0004024167,0.0002444653,0.0002897476,0.0003147607,0.000554217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001133379,"about_ca_system_score_gemma":0.0001642227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008246923,"about_ca_topic_score_gemma":0.001754908,"domain_scores_codex":[0.9999062,0.0000161344,0.000005836337,0.00004255793,0.00001524255,0.00001400632],"domain_scores_gemma":[0.9999001,0.0000176442,0.00002979068,0.00001891945,0.00001298005,0.00002058096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001086912,0.00005277093,0.1622403,0.0001755045,0.000294279,0.00556309,0.001239922,0.0002958523,0.7969034,0.001093451,0.000331398,0.03072314],"study_design_scores_gemma":[0.00002988367,0.0006231251,0.8540545,0.00006985162,0.0003783695,0.04697854,0.001879056,0.001940152,0.05837334,0.001594097,0.0340165,0.00006259268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954683,0.0006608031,0.001713688,0.00007553028,0.000021994,0.000007969065,0.0001829879,0.00002119332,0.001847552],"genre_scores_gemma":[0.9946072,0.0006643071,0.002938444,0.0001254949,0.00002046914,0.00001337353,0.0003855633,0.00003046789,0.001214695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002249115,"threshold_uncertainty_score":0.007524073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256859074738154,"score_gpt":0.2550943359426998,"score_spread":0.2425257451953183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}