{"id":"W3196313408","doi":"10.1080/22221751.2021.1976079","title":"Global DNA hypomethylation of Alu and LINE-1 transposable elements as an epigenetic biomarker of anti-tuberculosis drug-induced liver injury","year":2021,"lang":"en","type":"article","venue":"Emerging Microbes & Infections","topic":"Pneumocystis jirovecii pneumonia detection and treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculté de pharmacie, Université de Montréal; Health Systems Research Institute; Mahidol University","keywords":"Alu element; DNA methylation; Epigenetics; Methylation; Biomarker; Tuberculosis; Biology; Liver injury; Medicine; Immunology; DNA; Genetics; Pharmacology; Pathology; Human genome; Gene; Genome; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003255628,0.0001793196,0.0002498521,0.0007822433,0.0001229648,0.0002989607,0.0001783856,0.0002338425,0.0006097267],"category_scores_gemma":[0.0006697745,0.000145735,0.0001431954,0.0004657713,0.0002172592,0.000124781,0.0001630334,0.0001962829,0.00009521504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000117455,"about_ca_system_score_gemma":0.00006606947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006987083,"about_ca_topic_score_gemma":0.0009609473,"domain_scores_codex":[0.9997492,0.00006921394,0.00002415344,0.00008572511,0.00004737167,0.00002430648],"domain_scores_gemma":[0.9995261,0.00009879235,0.0002609807,0.00003695672,0.00004455966,0.00003259569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000764386,0.00006817786,0.9133881,0.00005615474,0.0001494169,0.0002160278,0.0001493085,0.000128221,0.07729663,0.00004870167,0.00005287645,0.007681906],"study_design_scores_gemma":[0.000007760733,0.000355185,0.989136,0.00000616993,0.00008509458,0.001139161,0.00008337798,0.0006120561,0.008258201,0.00005147199,0.0002614285,0.000004142477],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986928,0.0005664506,0.0004804287,0.0000121586,0.000001885826,0.000006356991,0.00008766638,0.00000754127,0.0001445974],"genre_scores_gemma":[0.9994575,0.00009832042,0.0002362702,0.00001048428,0.000003029554,0.000004616523,0.00008373611,0.000001286052,0.0001047172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007822433,"threshold_uncertainty_score":0.002039731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01476678385817996,"score_gpt":0.2947172631585112,"score_spread":0.2799504793003312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}