{"id":"W3196331804","doi":"10.1101/2021.09.02.458602","title":"Transcriptional control of hypoxic hyphal growth in the fungal pathogen <i>Candida albicans</i>","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval; Montreal Heart Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; European Bioinformatics Institute","keywords":"Candida albicans; Biology; Filamentation; Corpus albicans; DNA microarray; Gene; Transcription factor; Genetics; Cell biology; Microarray analysis techniques; Genetic screen; Mutant; Fungal protein; Gene expression profiling; Virulence; Transcriptional regulation; Phenotype; Regulation of gene expression; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100903,0.0003271093,0.0002131364,0.0002857186,0.0001627421,0.0003288362,0.0001774261,0.0001555533,0.001079703],"category_scores_gemma":[0.0001673673,0.0001086794,0.0002620494,0.0001433688,0.0002101338,0.00008094201,0.0003040713,0.0003604666,0.0003462884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004280028,"about_ca_system_score_gemma":0.0002333727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001609496,"about_ca_topic_score_gemma":0.001531692,"domain_scores_codex":[0.999791,0.00002434952,0.00001132919,0.00006299969,0.00006129636,0.00004914415],"domain_scores_gemma":[0.9998397,0.0000322191,0.00004302828,0.0000136321,0.00003492165,0.00003655439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007012838,0.00001183879,0.000403805,0.00001466739,0.000002147558,0.00001932011,0.000005652053,0.00004068524,0.9986112,0.00004430967,0.00005227926,0.0007238614],"study_design_scores_gemma":[0.00001403517,0.0001382944,0.06031742,0.00001145798,0.00001711951,0.0001915749,0.00007116103,0.002607892,0.9349698,0.00008932524,0.001561298,0.00001059336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923599,0.001070982,0.002900085,0.0001249021,0.00002671996,0.0000243989,0.001798869,0.0001588773,0.001535272],"genre_scores_gemma":[0.9934145,0.0004255244,0.00200586,0.0000997,0.00001414335,0.00003638823,0.002301306,0.00003968017,0.001662958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001609496,"threshold_uncertainty_score":0.003611982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01284872532016013,"score_gpt":0.2212460027722831,"score_spread":0.2083972774521229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}