{"id":"W3196359758","doi":"10.1093/nar/gkab785","title":"XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Ligue Contre le Cancer; Fonds National de la Recherche Luxembourg","keywords":"RAD51; Biology; Non-homologous end joining; Homologous recombination; RAD52; DNA damage; Ku80; Genome instability; Nuclease; DNA repair; Molecular biology; DNA; DNA repair protein XRCC4; Homologous chromosome; Cell biology; Genetics; DNA-binding protein; Nucleotide excision repair; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086752,0.000272104,0.0001800127,0.0001261335,0.0001182098,0.0003306542,0.0001474818,0.0001521206,0.001792756],"category_scores_gemma":[0.00006993122,0.0001573147,0.0001401378,0.00008634965,0.0001550563,0.0001467638,0.0001751569,0.0004212417,0.0004330072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001542833,"about_ca_system_score_gemma":0.0001531943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003137029,"about_ca_topic_score_gemma":0.0006510873,"domain_scores_codex":[0.9999202,0.00001474598,0.000007404879,0.00002017837,0.00001787772,0.00001950699],"domain_scores_gemma":[0.9999319,0.00000985073,0.00001910464,0.000008866387,0.000005566267,0.00002469377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001224349,0.00002643147,0.00007298181,0.00001893913,0.000002924929,0.00001357645,0.000004331332,0.00002018195,0.9992151,0.00004259761,0.00002853741,0.0004318614],"study_design_scores_gemma":[0.00002003931,0.0002372888,0.00312051,0.000003985431,0.00000710776,0.00009602121,0.00001317924,0.0005381453,0.9941028,0.00001812496,0.0018406,0.00000221455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995453,0.001467165,0.001259053,0.00009629047,0.00002831172,0.00001674542,0.0002693758,0.00007733985,0.001332615],"genre_scores_gemma":[0.9939584,0.0007353082,0.0008611943,0.00002809141,0.000009944724,0.00002371418,0.0004355335,0.00002374564,0.003924107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001792756,"threshold_uncertainty_score":0.00599736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04179084196335648,"score_gpt":0.3080594275981268,"score_spread":0.2662685856347703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}