{"id":"W3196374768","doi":"10.1093/genetics/iyab142","title":"Clonal evolution in serially passaged <i>Cryptococcus neoformans</i> × <i>deneoformans</i> hybrids reveals a heterogenous landscape of genomic change","year":2021,"lang":"en","type":"article","venue":"Genetics","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Canadian Institute for Advanced Research","keywords":"Biology; Genetics; Nondisjunction; Hybrid; Loss of heterozygosity; Mitotic crossover; Genome; Chromosome; Aneuploidy; Gene; Homologous recombination; Allele","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002286791,0.0002054871,0.000183382,0.0003161173,0.0002261017,0.0003305014,0.0002408081,0.0002463479,0.0004506834],"category_scores_gemma":[0.000279043,0.00010132,0.0002187333,0.0002651395,0.0001452792,0.0001094597,0.0003284177,0.0004877925,0.0001002327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000343132,"about_ca_system_score_gemma":0.0001364651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001686912,"about_ca_topic_score_gemma":0.002876637,"domain_scores_codex":[0.9998172,0.0000223286,0.00001822258,0.00005297818,0.00004971545,0.00003960831],"domain_scores_gemma":[0.9997784,0.00007209172,0.00004944562,0.00003518157,0.00003106922,0.00003373623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005218057,0.00004238938,0.002222728,0.00001177422,0.00001075728,0.00007768546,0.00004061676,0.0001836543,0.9940142,0.00007231599,0.0000155618,0.003256163],"study_design_scores_gemma":[0.00002719702,0.001676017,0.2181672,0.0000182796,0.00008459637,0.001634495,0.0003521025,0.005936559,0.7675925,0.0001604662,0.004305068,0.00004548624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983332,0.00006914235,0.0008305311,0.00001152785,0.000004125638,0.00002302162,0.0001551057,0.00001519612,0.0005581501],"genre_scores_gemma":[0.9952715,0.00009680396,0.002723093,0.00003507281,0.000003627551,0.00003019212,0.0006976781,0.00002308783,0.001118884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001686912,"threshold_uncertainty_score":0.003354251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02331416016425087,"score_gpt":0.2558334830254249,"score_spread":0.232519322861174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}