{"id":"W3196377280","doi":"10.1021/acschembio.1c00390","title":"Development of a Benzothiazole Scaffold-Based Androgen Receptor N-Terminal Inhibitor for Treating Androgen-Responsive Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Deutsche Forschungsgemeinschaft; Wilhelm Sander-Stiftung; Prostate Cancer Foundation","keywords":"Androgen receptor; Benzothiazole; Prostate cancer; Scaffold; Androgen; Terminal (telecommunication); Prostate; Chemistry; Cancer research; Cancer; Endocrinology; Internal medicine; Medicine; Hormone; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138469,0.000172653,0.0004177544,0.00006871211,0.0000712218,0.000006973103,0.00007210102,0.0001773157,0.0001284696],"category_scores_gemma":[0.0001747064,0.0001319142,0.000103805,0.0001944901,0.000159557,0.00002476936,0.00006799828,0.0001073659,0.000006263766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001868182,"about_ca_system_score_gemma":0.001328446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008242142,"about_ca_topic_score_gemma":0.00000728805,"domain_scores_codex":[0.9986831,0.00003740181,0.0003674794,0.000385346,0.0001267227,0.0003999307],"domain_scores_gemma":[0.9990283,0.0001831458,0.0001058954,0.000166958,0.000363262,0.0001524601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002511086,0.0002281153,0.008049186,0.0002562291,0.0001883692,0.00002909394,0.0006104004,2.961963e-7,0.9542968,0.0000167435,0.0003590282,0.0334546],"study_design_scores_gemma":[0.00453245,0.0002583569,0.00009088749,0.0001980679,0.00006633873,0.0000195755,0.0001411542,0.00002856239,0.9766936,0.00003028393,0.01780558,0.0001350935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955862,0.002354516,0.0000205727,0.001075063,0.00007626649,0.000586052,0.0002153034,0.00002549903,0.00006053405],"genre_scores_gemma":[0.981078,0.0001377495,0.01608455,0.0002740096,0.0001723288,0.0005949807,0.001115191,0.00002894891,0.0005142119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03331951,"threshold_uncertainty_score":0.5379305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02979726984447149,"score_gpt":0.337623279651928,"score_spread":0.3078260098074565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}