{"id":"W3196377280","doi":"10.1021/acschembio.1c00390","title":"Development of a Benzothiazole Scaffold-Based Androgen Receptor N-Terminal Inhibitor for Treating Androgen-Responsive Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Deutsche Forschungsgemeinschaft; Wilhelm Sander-Stiftung; Prostate Cancer Foundation","keywords":"Androgen receptor; Benzothiazole; Prostate cancer; Scaffold; Androgen; Terminal (telecommunication); Prostate; Chemistry; Cancer research; Cancer; Endocrinology; Internal medicine; Medicine; Hormone; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031632,0.0003148495,0.0003102772,0.0002124113,0.0001726293,0.0001941996,0.000393105,0.0002407422,0.001511824],"category_scores_gemma":[0.00005917834,0.0001434656,0.0002480288,0.0001979746,0.0001422576,0.0001383716,0.0001461708,0.0005231036,0.0005192403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003481929,"about_ca_system_score_gemma":0.0004385511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001818011,"about_ca_topic_score_gemma":0.004344743,"domain_scores_codex":[0.9999423,0.000007106923,0.000002862685,0.00001030904,0.00001789879,0.00001952454],"domain_scores_gemma":[0.9999738,0.000002402724,0.000007298516,0.000001756961,0.000005929364,0.000008836218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001854708,0.0001596754,0.000226206,0.0002073849,0.0000301658,0.0001729482,0.00003014452,0.000763475,0.983007,0.0004844592,0.0006773245,0.01405578],"study_design_scores_gemma":[0.0006846448,0.004952685,0.006163464,0.00004243334,0.0001475174,0.001302739,0.00004016519,0.006695719,0.9434904,0.00014389,0.03628407,0.00005221436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9429747,0.01983699,0.02017221,0.0008962039,0.0002024147,0.0005727833,0.00126086,0.0007270194,0.01335686],"genre_scores_gemma":[0.9709539,0.01067102,0.0103349,0.0002667973,0.00003354765,0.0001745718,0.00116263,0.00002678731,0.006375758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001818011,"threshold_uncertainty_score":0.005057514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02979726984447149,"score_gpt":0.337623279651928,"score_spread":0.3078260098074565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}