{"id":"W3196377505","doi":"10.1128/spectrum.00918-21","title":"The Next-Generation β-Lactamase Inhibitor Taniborbactam Restores the Morphological Effects of Cefepime in KPC-Producing Escherichia coli","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institute of Allergy and Infectious Diseases; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Wellcome Trust","keywords":"Cefepime; Escherichia coli; Microbiology; Antibiotics; Antimicrobial; Biology; Antibiotic resistance; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004135242,0.0002012031,0.0002438258,0.00002319989,0.0001824988,0.00004600261,0.0003407117,0.0002701174,0.00002124784],"category_scores_gemma":[0.0005356891,0.0001275114,0.0001003798,0.0001797604,0.0004535105,0.000005877677,0.0002748417,0.0002357109,0.000009665554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004515772,"about_ca_system_score_gemma":0.0001476609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000343717,"about_ca_topic_score_gemma":0.0006443062,"domain_scores_codex":[0.998202,0.0004565667,0.0003753804,0.0005117963,0.00005527185,0.0003989571],"domain_scores_gemma":[0.9989398,0.0001337256,0.0001757373,0.0006645006,0.00005126371,0.00003502581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001091059,0.00007339202,0.006003075,0.0000176453,0.00004088469,0.00004198926,0.00004787201,0.0000131741,0.9902636,0.0002559366,0.003027506,0.0001058645],"study_design_scores_gemma":[0.0003918406,0.0001989986,0.02546757,0.00002402712,0.00001648516,0.00006218489,0.00007043903,0.00001294235,0.9655734,0.00009089266,0.007938081,0.0001531467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932856,0.003345673,0.00007000833,0.002059313,0.0008019836,0.0002904793,0.00001328225,0.000009594888,0.0001240517],"genre_scores_gemma":[0.9975953,0.0005784731,0.0003762157,0.0003646363,0.0004928866,0.00001386972,0.0001395757,0.00002066559,0.0004184437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02469016,"threshold_uncertainty_score":0.5199766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328859543244242,"score_gpt":0.2290370341096675,"score_spread":0.2157484386772251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}