{"id":"W3196430494","doi":"10.7150/thno.60679","title":"Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma","year":2021,"lang":"en","type":"article","venue":"Theranostics","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; NIH Office of the Director; Bundesministerium für Bildung und Forschung; Deutsches Krebsforschungszentrum; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst; National Institutes of Health; Universitätsklinikum Heidelberg; Ministère de l'Économie, de la Science et de l'Innovation - Québec; European Commission","keywords":"Aryl hydrocarbon receptor; Kynurenine; Metabolite; Catabolism; Metabolism; Cancer research; Tryptophan; Chemistry; Kynurenine pathway; Tumor progression; Tumor microenvironment; Internal medicine; Biology; Biochemistry; Medicine; Amino acid; Gene; Tumor cells; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005587421,0.0001135835,0.0001553787,0.0000496495,0.00003332382,0.00002487177,0.0001602891,0.00002752226,0.00002721846],"category_scores_gemma":[0.0002055252,0.00007422288,0.00002412258,0.0004748508,0.0001722629,0.0000603871,0.00003333536,0.0001022595,0.000001799241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002920217,"about_ca_system_score_gemma":0.00003256717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006877176,"about_ca_topic_score_gemma":0.00001952388,"domain_scores_codex":[0.9990776,0.0001404475,0.000153921,0.0002124266,0.0002516271,0.0001639689],"domain_scores_gemma":[0.9994063,0.0002086863,0.00006993848,0.0002357895,0.00004799782,0.0000312901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001921517,0.00382594,0.0360347,0.0002281702,0.0001252546,0.0005631845,0.02889553,0.00007155829,0.8963817,0.02078752,0.0009469372,0.01021799],"study_design_scores_gemma":[0.004183321,0.0002384967,0.2239393,0.00003900225,0.00004191144,0.00002014786,0.0004805702,0.00008835828,0.7676013,0.001429506,0.001747659,0.0001904626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990867,0.0001631838,0.000007929243,0.0002354351,0.00004545684,0.0002030871,0.0000265338,0.00003586408,0.0001958505],"genre_scores_gemma":[0.9974828,0.0000382355,0.00009343546,0.002313161,0.00001141619,0.000004595503,0.000001324203,0.00002506345,0.00002993922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1879046,"threshold_uncertainty_score":0.3026721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009763529848349588,"score_gpt":0.2056131869817096,"score_spread":0.19584965713336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}