{"id":"W3196430494","doi":"10.7150/thno.60679","title":"Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma","year":2021,"lang":"en","type":"article","venue":"Theranostics","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; NIH Office of the Director; Bundesministerium für Bildung und Forschung; Deutsches Krebsforschungszentrum; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst; National Institutes of Health; Universitätsklinikum Heidelberg; Ministère de l'Économie, de la Science et de l'Innovation - Québec; European Commission","keywords":"Aryl hydrocarbon receptor; Kynurenine; Metabolite; Catabolism; Metabolism; Cancer research; Tryptophan; Chemistry; Kynurenine pathway; Tumor progression; Tumor microenvironment; Internal medicine; Biology; Biochemistry; Medicine; Amino acid; Gene; Tumor cells; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000083188,0.0001467279,0.000313045,0.0004056877,0.0002440042,0.0003919624,0.0001091192,0.0002395514,0.0009359394],"category_scores_gemma":[0.000552212,0.0001049094,0.00010558,0.0005213417,0.0001489668,0.0001455985,0.0001521205,0.000338065,0.0001658918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002485652,"about_ca_system_score_gemma":0.0001735279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002580554,"about_ca_topic_score_gemma":0.00405667,"domain_scores_codex":[0.9998899,0.0000253975,0.000007613723,0.00002922348,0.00002018949,0.00002779346],"domain_scores_gemma":[0.9998052,0.00003213777,0.00007834443,0.00001184346,0.00003506367,0.00003757874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002963185,0.00009024564,0.943498,0.00003863597,0.0001388141,0.0007031968,0.000193972,0.0000737997,0.03879878,0.00008455185,0.0004898091,0.0129271],"study_design_scores_gemma":[0.00001707112,0.0002508049,0.9954559,0.000005541826,0.00008635572,0.0006747275,0.0002092536,0.0002383308,0.00210335,0.00012699,0.0008257341,0.000006148346],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981669,0.0005305255,0.0002128744,0.00009106215,0.00001155176,0.000005173551,0.0003512606,0.00001105466,0.0006195424],"genre_scores_gemma":[0.9989251,0.0001748686,0.000125878,0.00005780441,0.00000915396,0.000006953322,0.0003254261,0.000004458953,0.0003702023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002580554,"threshold_uncertainty_score":0.005131125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009763529848349588,"score_gpt":0.2056131869817096,"score_spread":0.19584965713336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}