{"id":"W3196473730","doi":"10.1038/s41467-021-25467-w","title":"Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University; Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University Health Network; University of Toronto; SickKids Foundation; Hospital for Sick Children; Ontario Institute for Cancer Research","funders":"Congressionally Directed Medical Research Programs; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Foundation; Canadian International Development Agency; U.S. Department of Defense; International Development Research Centre; Government of Canada","keywords":"Biology; Haploinsufficiency; Genetics; Allele; Suppressor; Breast cancer; Gene; Chromosome; Cancer research; Cancer; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005210256,0.00006791735,0.00008382171,0.00002820235,0.0001009965,0.00001738378,0.0001214673,0.0001586919,0.00002681862],"category_scores_gemma":[0.00007278051,0.00007533288,0.00002813879,0.0001782649,0.0001176121,0.000004858757,0.0001316634,0.0002190592,4.588481e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002678764,"about_ca_system_score_gemma":0.0001791403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003341891,"about_ca_topic_score_gemma":0.003817723,"domain_scores_codex":[0.9995383,0.00005749258,0.0001316452,0.0001424127,0.00004648992,0.00008367321],"domain_scores_gemma":[0.9991709,0.00006943924,0.00005101964,0.0003554561,0.00032227,0.00003092932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003406727,0.002224085,0.2555671,0.00005988338,0.0007628782,0.000009939852,0.0005749043,0.07404496,0.5304652,0.0890721,0.03762545,0.009252777],"study_design_scores_gemma":[0.003613975,0.0003207408,0.7262855,0.000130589,0.0002314281,0.0001890952,0.0006763519,0.01382219,0.03592254,0.002048661,0.2158846,0.0008743865],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.884913,0.0910343,0.006826973,0.01193617,0.0003415413,0.0004756502,0.001567601,0.00002016212,0.002884648],"genre_scores_gemma":[0.9912618,0.005171031,0.0006946254,0.0005288069,0.00006612162,0.00004252635,0.002177878,0.000008799137,0.00004845284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4945427,"threshold_uncertainty_score":0.3071986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013410805565588,"score_gpt":0.2781421369031729,"score_spread":0.268008028847517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}