{"id":"W3196474089","doi":"10.3389/fimmu.2021.725204","title":"Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers via Dormancy Regulation","year":2021,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Chengdu University; Chengdu University of Traditional Chinese Medicine; Government of Jiangsu Province; Natural Science Foundation of Jiangsu Province; Jiangxi University of Traditional Chinese Medicine; Mitacs; China Postdoctoral Science Foundation","keywords":"Dormancy; Indoleamine 2,3-dioxygenase; Kynurenine; Aryl hydrocarbon receptor; Cancer research; Metastasis; Kynurenine pathway; Biology; Cancer; Medicine; Internal medicine; Tryptophan; Biochemistry; Botany; Gene; Transcription factor; Germination","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001833996,0.0004348607,0.0005513208,0.001006817,0.0001596604,0.0005434101,0.0004110176,0.0006461199,0.002117359],"category_scores_gemma":[0.0001703946,0.000146087,0.0002896225,0.0006422891,0.0002162069,0.0006834294,0.0003706694,0.001058548,0.001325107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000338344,"about_ca_system_score_gemma":0.0004277326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004488385,"about_ca_topic_score_gemma":0.001031887,"domain_scores_codex":[0.9999506,0.000007326724,0.000005202297,0.000009223821,0.00001906038,0.000008497155],"domain_scores_gemma":[0.9999493,0.00001636187,0.000009663538,0.000001905333,0.00001489047,0.000007866686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001165205,0.0001012852,0.0001876203,0.01567614,0.00008507654,0.0003402831,0.00006689647,0.0005269494,0.01673351,0.006652154,0.02558652,0.9339271],"study_design_scores_gemma":[0.00001894959,0.000196242,0.0007308729,0.001376905,0.00008035213,0.00139604,0.00004381646,0.0001825094,0.003375892,0.002318608,0.9902636,0.00001627627],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005765794,0.9966729,0.0003791465,0.0002981014,0.0002746587,0.000008853349,0.00002955237,0.00001490532,0.001745313],"genre_scores_gemma":[0.00256777,0.9953474,0.0002722954,0.0001754748,0.0001468426,0.000009894297,0.0000468552,0.000002286956,0.001431259],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002117359,"threshold_uncertainty_score":0.007083297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02377853747860601,"score_gpt":0.2769968111933462,"score_spread":0.2532182737147402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}