{"id":"W3196490516","doi":"10.1093/nar/gkab761","title":"Increase in lamin B1 promotes telomere instability by disrupting the shelterin complex in human cells","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; CNIB; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; California Earthquake Authority","keywords":"Shelterin; Telomere; Lamin; Biology; Genome instability; Telomere-binding protein; Cell biology; DNA replication; Progeria; Genetics; DNA damage; Transcription factor; DNA; DNA-binding protein; Gene; Nucleus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009714001,0.0001196697,0.0001401523,0.00006599379,0.0001952088,0.00006980998,0.0002723573,0.0001464855,0.000257228],"category_scores_gemma":[0.0002513884,0.00009697406,0.00004554722,0.0004000061,0.0002202065,0.000007835325,0.0004153952,0.0004722725,0.00001498033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000596137,"about_ca_system_score_gemma":0.00007558592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004495387,"about_ca_topic_score_gemma":0.0009371267,"domain_scores_codex":[0.9981145,0.0005227234,0.0002357413,0.0004373667,0.0002766824,0.0004130196],"domain_scores_gemma":[0.9992607,0.00004442572,0.00002826536,0.000493685,0.0001060368,0.00006693092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005917597,0.0001114331,0.01992546,0.00003514675,0.000007352234,0.00001851066,0.0002173295,0.000003150087,0.9714943,0.00008718191,0.001711064,0.006329882],"study_design_scores_gemma":[0.001491648,0.0004544632,0.2085433,0.00005252686,0.000005389255,0.00002533694,0.002444078,0.0003249621,0.6714907,0.0008479428,0.1139354,0.0003842165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995421,0.0001519884,0.00001007438,0.0004191325,0.00003581325,0.0002438328,0.0000214774,0.000007642267,0.003689032],"genre_scores_gemma":[0.9989516,0.00003559191,0.0002241671,0.00009863976,0.00009614086,0.00002162531,0.0001148283,0.00002326819,0.0004341971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3000036,"threshold_uncertainty_score":0.3954488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03359166435688481,"score_gpt":0.3340974166665314,"score_spread":0.3005057523096465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}