{"id":"W3196490516","doi":"10.1093/nar/gkab761","title":"Increase in lamin B1 promotes telomere instability by disrupting the shelterin complex in human cells","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; CNIB; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; California Earthquake Authority","keywords":"Shelterin; Telomere; Lamin; Biology; Genome instability; Telomere-binding protein; Cell biology; DNA replication; Progeria; Genetics; DNA damage; Transcription factor; DNA; DNA-binding protein; Gene; Nucleus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417487,0.0002117509,0.0002225489,0.0002278088,0.0001867877,0.0002965282,0.00009839996,0.0002475518,0.001394863],"category_scores_gemma":[0.00008955859,0.0001359799,0.0001873742,0.0001819669,0.0001276384,0.0001147262,0.0001771563,0.0002654041,0.0004128617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002312768,"about_ca_system_score_gemma":0.0001508203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008327438,"about_ca_topic_score_gemma":0.0006322375,"domain_scores_codex":[0.9999025,0.00001969309,0.00001188514,0.00002556326,0.00002075303,0.00001956763],"domain_scores_gemma":[0.9999493,0.000006849632,0.00001456102,0.000008512278,0.000005448866,0.0000152871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001532208,0.0000241901,0.0003334869,0.00002612275,0.000009670297,0.00007528452,0.00001967481,0.00003226745,0.9984963,0.00004277063,0.00003847908,0.0007486522],"study_design_scores_gemma":[0.00002117531,0.0003856246,0.01008718,0.000007801246,0.00002929215,0.0006797441,0.00005596472,0.0006319669,0.9843534,0.00005760148,0.003685011,0.000005227767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947085,0.002886584,0.001265643,0.00008535099,0.00001602018,0.00001410514,0.0001845865,0.00007721253,0.0007619387],"genre_scores_gemma":[0.9965013,0.0009748577,0.0005665768,0.00004098163,0.000005961919,0.00001703301,0.000347898,0.000009300426,0.001536103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001394863,"threshold_uncertainty_score":0.004666269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03359166435688481,"score_gpt":0.3340974166665314,"score_spread":0.3005057523096465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}